Publications by authors named "Mohamad Fadhli Bin Masri"
Biomarkers in the evaluation of cardiac involvement in systemic sclerosis.
Rheumatol Immunol Res
June 2024
Systemic sclerosis is a multisystemic disease for which the heart can be affected leading to cardiac complications and mortality. Up to 80% of patients with systemic sclerosis have cardiac involvement with varying levels of severity. Several molecules have been identified that can be used as markers of cardiac involvement.
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- Dengue virus (DENV) causes thrombocytopenia, a drop in platelet counts, during infection, but the exact mechanism behind this is unclear.
- Research shows that mast cells release serotonin during DENV infection, which leads to activated platelets and increased phagocytosis, contributing to the thrombocytopenia.
- Targeting serotonin receptors in treatment can potentially prevent this platelet drop, making mast cell-derived serotonin a promising new area for therapeutic intervention.