Publications by authors named "Mohamad Azmeer Effendy"
Article Synopsis
- Mitragynine, derived from Kratom, has been shown to alter synaptic transmission in the hippocampus, but its specific effects on glutamatergic neurotransmission and synaptic plasticity remain unclear.
- Researchers investigated the involvement of AMPA and NMDA glutamate receptors in mitragynine's impact on synaptic changes by administering the substance to rats and assessing synaptic activity through recorded responses.
- The results indicated that mitragynine, along with the receptor antagonists (NBQX for AMPA and MK-801 for NMDA), disrupted baseline synaptic transmission and long-term potentiation (LTP), suggesting that mitragynine may act as a weak antagonist for both types of receptors without affecting paired-p
Background: Mitragynine, the major indole alkaloid from Mitragyna speciosa has been reported previously to possess abuse liability. However, there are insufficient data suggesting the mechanism through which this pharmacological agent causes addiction.
Aims: In this study, we investigated the effects of mitragynine on dopamine (DA) level and dopamine transporter (DAT) expression from the rat's frontal cortex.
Cerebral ischemia is a result of insufficient blood flow to the brain. It leads to limited supply of oxygen and other nutrients to meet metabolic demands. These phenomena lead to brain damage.
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