Publications by authors named "Mohaddeseh Mahboubi"
Evaluation of OipA protein as a vaccine candidate and propolis as an adjuvant in C57BL/6 mice.
Iran J Basic Med Sci
September 2021
Objectives: Outer inflammatory protein A (OipA) is an essential adhesin of . We aimed to evaluate the effects of a recombinant OipA in the induction of crucial cytokines as a vaccine candidate and propolis as an adjuvant in C57BL/6 mice.
Materials And Methods: C57BL/6 mice were divided into nine groups according to the disposition of antigen and adjuvant and route of administration: subcutaneous (sc) or gavage.
Background: Regarding the important role of proinflammatory outer membrane protein (OipA) in the pathogenesis of infection and immunomodulatory activity of propolis, we aimed to evaluate the immunogenicity effect of a purified recombinant OipA protein and propolis in the induction of two cytokines, interferon-gamma (IFN-γ) and interleukin-4 (IL-4), in a macrophage cell model.
Materials And Methods: The recombinant protein used in the present study corresponding to the expressing a 34-35 kDa protein. OipA protein was purified by Ni-NTA affinity chromatography.