Targeted drug delivery of Sunitinib Malate to tumor blood vessels by cRGD-chiotosan-gold nanoparticles.

The unique characteristics of tumor vasculature represent an attractive strategy for targeted delivery of antitumor and antiangiogenic agents to the tumor. The purpose of this study was to prepare c(RGDfK) labeled chitosan capped gold nanoparticles [cRGD(CS-Au) NPs] as a carrier for selective intracellular delivery of Sunitinib Malate (STB) to the tumor vasculature. cRGD(CS-Au) NPs was formed by electrostatic interaction between cationic CS and anionic AuNPs.

Role of four-week resistance exercise in preserving the heart against ischaemia-reperfusion-induced injury.

Objective: We studied the cardioprotective effect of resistance training against ischaemia-reperfusion-induced injury.

Methods: Forty male rats were divided into trained and sedentary groups (n = 20 for each). The trained rats were exercised at 12 repetitions/set, four sets/day and five days/week for four weeks.

Role of 12-week resistance training in preserving the heart against ischemia-reperfusion-induced injury.

Background: Discovering an effective approach to provide cardioprotection against coronary artery disease has long been sought. We studied the cardioprotective effect of resistance training against ischemia-reperfusion-induced injury.

Methods: Twenty male rats were divided into trained and sedentary groups (n = 10 in each).