Optimizing functionally graded tibial components for total knee replacements: a finite element analysis and multi-objective optimization study.

The optimal design of complex engineering systems requires tracing precise mathematical modeling of the system's behavior as a function of a set of design variables to achieve the desired design. Despite the success of current tibial components of knee implants, the limited lifespan remains the main concern of these complex systems. The mismatch between the properties of engineered biomaterials and those of biological materials leads to inadequate bonding with bone and the stress-shielding effect.