Publications by authors named "Mohab Ragab"
Article Synopsis
- Vasoactive intestinal peptide (VIP) plays a crucial role in intestinal health, influencing epithelial cell turnover and differentiation, especially under injury conditions like irradiation.
- VIP promotes the differentiation of intestinal epithelial cells and boosts progenitor cell proliferation, primarily through the p38 MAPK signaling pathway.
- In mouse models, VIP not only enhances recovery from radiation-induced damage but also demonstrates potential protective effects on intestinal cells during injury.
Paneth cells (PCs), a subset of intestinal epithelial cells (IECs) found at the base of small intestinal crypts, play an essential role in maintaining intestinal homeostasis. Altered PCs function is associated with diverse intestinal pathologies, including ileal Crohn's disease (CD). CD patients with ileal involvement have been previously demonstrated to display impairment in PCs and decreased levels of anti-microbial peptides.
View Article and Find Full Text PDFType 2 Diabetes Mellitus has reached epidemic levels globally, and several studies have confirmed a link between gut microbial dysbiosis and aberrant glucose homeostasis among people with diabetes. While the assumption is that abnormal metabolomic signatures would often accompany microbial dysbiosis, the connection remains largely unknown. In this study, we investigated how diet changed the gut bacteriome, mycobiome and metabolome in people with and without type 2 Diabetes.
View Article and Find Full Text PDFArticle Synopsis
- COVID-19 is linked to significant metabolic disruptions, showing a specific serum profile associated with severe lipid abnormalities when compared to healthy individuals.
- In a study analyzing 482 serum samples, COVID-19 patients displayed increased levels of certain lipoproteins while having decreased cholesterol, indicating altered metabolic status.
- The distinct metabolic profile of COVID-19 patients sets them apart not only from healthy controls but also from other serious conditions like cardiogenic shock, suggesting unique implications for lipid metabolism in the disease.
To enable rapid proliferation, colorectal tumor cells up-regulate epidermal growth factor receptor (EGFR) signaling and aerobic glycolysis, resulting in substantial lactate release into the tumor microenvironment and impaired anti-tumor immune responses. We hypothesized that a nutritional intervention designed to reduce aerobic glycolysis may boost the EGFR-directed antibody (Ab)-based therapy of pre-existing colitis-driven colorectal carcinoma (CRC). CRC development was induced by azoxymethane (AOM) and dextran sodium sulfate (DSS) administration to C57BL/6 mice.
View Article and Find Full Text PDFLoss of Mucosal p32/gC1qR/HABP1 Triggers Energy Deficiency and Impairs Goblet Cell Differentiation in Ulcerative Colitis.
Cell Mol Gastroenterol Hepatol
January 2022
Article Synopsis
- Cell differentiation in the colon relies on switching from glycolysis to mitochondrial oxidation, with dysfunction in these processes linked to ulcerative colitis (UC) pathology.* -
- Research showed that decreased expression of p32, a key player in oxidative phosphorylation, correlates with impaired goblet cell differentiation in UC patients, leading to a deficiency in mucus production.* -
- Nutritional interventions, like a high-protein diet, can boost p32 levels and promote goblet cell differentiation in mice, suggesting potential therapeutic strategies for UC management.*
Non-celiac wheat sensitivity (NCWS) has been proposed to be an independent disease entity that is characterized by intestinal (e.g., abdominal pain, flatulence) and extra-intestinal symptoms (e.
View Article and Find Full Text PDFFood allergies are common, costly and potentially life-threatening disorders. They are driven by Th2, but inhibited by Th1 reactions. There is also evidence indicating that IL-2 agonist treatment inhibits allergic sensitization through expansion of regulatory T cells.
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