Study of gamma radiation shielding on tellurite glass containing TiO and AlO nanoparticles.

Radiation shielding incorporates material between the radioactive source and environment to decrease exposure to hazardous radiation. It remains to be seen whether the addition of nanoparticles effectively increases the protection of tellurite glass system from further degradation under irradiation conditions. This study revealed the gamma radiation effects on tellurite glass.

Effect of monsoon on microplastic bioavailability and ingestion by zooplankton in tropical coastal waters of Sabah.

Plankton seasonality in tropical coastal waters is becoming more apparent as a result of monsoon-driven changes in environmental conditions, but research on the monsoonal variation of microplastics (MP) is still limited. We examined the monsoonal variation of MP in the water column and their ingestion by zooplankton in Sepanggar Bay, Sabah, Malaysia. MP concentrations were significantly higher during the Southwest monsoon whereas MP ingestions showed no monsoonal difference across major zooplankton taxa.

Peptide Conjugate on Multilayer Graphene Oxide Film for the Osteogenic Differentiation of Human Wharton's Jelly-Derived Mesenchymal Stem Cells.

Graphene oxide (GO) is extensively studied as a template material for mesenchymal stem cell application due to its two-dimensional nature and unique functionalization chemistries. Herein, a new type of peptide-conjugated multilayer graphene oxide (peptide/m-GO film) was fabricated and used as biomaterial for culturing human Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs). The characterization of the peptide/m-GO films was performed, and the biocompatibility of the WJ-MSCs on the peptide/m-GO films was investigated.

An Evaluation-Focused Framework for Visualization Recommendation Algorithms.

Although we have seen a proliferation of algorithms for recommending visualizations, these algorithms are rarely compared with one another, making it difficult to ascertain which algorithm is best for a given visual analysis scenario. Though several formal frameworks have been proposed in response, we believe this issue persists because visualization recommendation algorithms are inadequately specified from an evaluation perspective. In this paper, we propose an evaluation-focused framework to contextualize and compare a broad range of visualization recommendation algorithms.

Blount disease and familial inheritance in Ghana, area cross-sectional study.

Objective: The objective of this study is to study familial inheritance for Blount disease to create better understanding of the aetiology of Blount disease.

Methods: After reviewing patient files and conventional roentgenologic imaging, 139 patients with Blount disease were included in this cross-sectional study, of which 102 patients were interviewed. During the interviews, patient characteristics and family history were collected.

Insight into the possible aetiologies of Blount's disease: a systematic review of the literature.

Blount's disease or bowed leg deformity, is a unilateral or bilateral growth deformity of the medial proximal tibia that leads to a tibial varus deformity. A distinction can be made in an early and late onset type. The disease seems to have a predisposition for certain descends.

Extractable impurities from fluoropolymer-based membrane filters - interference in high-throughput, untargeted analysis.

The removal of particles using fluoropolymer-based membrane filters is usually done so to prolong the life span of an analytical column, prevent hardware damage, and reduce signal suppression. Ironically, these membrane filters tend to leach impurities into the samples as the samples are filtered through them. These impurities have the potential to affect the researcher's interpretation in high-throughput, non-targeted analysis.

PRMT1 loss sensitizes cells to PRMT5 inhibition.

PRMT5 is an arginine methyltransferase that accounts for the vast majority of the symmetric methylation in cells. PRMT5 exerts its function when complexed with MEP50/WDR77. This activity is often elevated in cancer cells and correlates with poor prognosis, making PRMT5 a therapeutic target.

Treatment strategies for chronic osteomyelitis in low- and middle-income countries: systematic review.

Objectives: To identify a standard treatment regime or highly successful procedure for chronic osteomyelitis in low- and middle-income countries.

Methods: Systematic review following PRISMA guidelines.

Results: The initial search resulted in 102 studies of which nine met the inclusion criteria and were analysed qualitatively.

W/M serrated osteotomy for infantile Blount's disease in Ghana: Short-term results.

Purpose: The W/M serrated high tibial osteotomy is a not frequently described surgical technique for simultaneously correcting the varus and torsional deformity in patients with Blount's disease. Without the need for internal fixation, this surgical treatment is well suited for developing countries. This study describes the short-term results of the bilateral and unilateral W/M serrated osteotomy in patients with infantile Blount's disease.

Revelation of the molecular assembly of the nanoporous metal organic framework ZIF-8.

Crystalline nanoporous materials are one of the most important families of complex functional material. Many questions pertaining to the molecular assembly mechanism of the framework of these materials remain unanswered. Only recently has it become possible to answer definitively some of these questions by observation of growing nanoscopic surface features on metal organic frameworks (MOFs) through use of in situ atomic force microscopy (AFM).

The role of microvascular injury in the evolution of idiopathic pulmonary fibrosis.

Interstitial lung disease compatible with idiopathic pulmonary fibrosis (IPF) developed in 19 previously healthy patients. Although interstitial and/or honeycomb parenchymal fibrosis was present in all, there were patchy areas of paucicellular septal capillary injury along with corroborative direct immunofluorescent evidence of a humorally mediated microvascular injury syndrome. Significantly elevated factor VIII levels were seen in 17 of 18 patients tested.

Primary anti-phospholipid antibody syndrome caused by isolated anti-phosphatidylethanolamine antibodies presenting as cryptogenic fibrosing alveolitis with recurrent pulmonary hemorrhage after single-lung transplantation.

A 28-year-old man underwent a single-lung transplantation for rapidly progressive usual interstitial pneumonitis. Following transplantation, primary anti-phospholipid antibody syndrome was diagnosed after a thromboembolic event and continued dyspnea. Review of his native lung and allograft tissue showed diffuse hemorrhage secondary to capillary injury, probably reflecting anti-phospholipid antibody effects on endothelia.

Diagnosis of acute appendicitis: comparison of 5- and 10-mm CT sections in the same patient.

Purpose: To compare 5- and 10-mm computed tomographic (CT) sections in the same patient to diagnose acute appendicitis.

Materials And Methods: During an 11-month period, 100 consecutive patients clinically suspected to have acute appendicitis underwent abdominal and pelvic CT. Helical, 10-mm-collimated sections from the diaphragm to the pubic symphysis and 5-mm-collimated sections through the lower part of the abdomen and upper part of the pelvis were obtained.

Effect of gossypol on 5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase activities in adult rat testes.

It has been reported that little to no 5 alpha-reductase can be detected in adult rat testes when progesterone is used as substrate. The 5 alpha-reductase activity in 4-month-old rats and the inhibitory action of gossypol on steroidobiosynthesis were studied. Testicular sections (10 microns thickness) were incubated at 30.

Steroidal inhibitors as chemical probes of the active site of aromatase.

Androstenedione analogs containing 7 alpha-substituents have proven to be potent inhibitors of aromatase in human placental microsomes, in MCF-7 mammary cell cultures, and in JAr choriocarcinoma cells. Recent investigations have focused on the use of mechanism-based inhibitors, such as 7 alpha-substituted 1,4-androstadienediones, to biochemically probe the active site of aromatase. Inhibition kinetics were determined under initial velocity conditions using purified human placental cytochrome P450arom protein in a reconstituted system.

In vitro uptake and autoradiographic localization of tritiated gossypol in Taenia taeniaeformis metacestodes.

Gossypol, a natural polyphenolic compound, induces growth-inhibitory and antiparasitic effects in Taenia taeniaeformis metacestodes in vivo and in vitro. We investigated the uptake and localization of [3H]-gossypol in this parasite. Metacestodes were incubated in 10(-5) M [3H]-gossypol at 37 degrees C.

Characteristics of covalent gossypol binding to microsomal proteins.

Gossypol is a potent antifertility agent contained in seeds and other parts of cotton plants. The limit set in 1974 by the FDA for this C30H30O8 compound in consumer products is 450 ppm. The binding characteristics and the nature of the microsomal protein adducts of radiolabeled gossypol were studied using centrifugation, extraction, reverse phase HPLC and filter assay approaches.

Transfer of 3H-gossypol to neonatal rats via milk of nursing dams.

Gossypol is a naturally occurring toxin with potent antifertility action in both males and females. Transfer of gossypol via milk from lactating mother to neonates has not been documented. One theory for the lack of such a finding is that gossypol, once tightly bound to milk proteins, is not extractable by conventional extraction methods for HPLC analysis.

Biochemical and pharmacological development of steroidal inhibitors of aromatase.

Androstenedione analogs containing 7 alpha-substituents have proven to be potent inhibitors of aromatase both in vitro and in vivo. Several of these agents have exhibited higher affinity for the enzyme complex than the substrate. In order to examine further the interaction(s) of 7-substituted steroids with aromatase, biochemical and pharmacological studies were performed on 7 alpha-thiosubstituted androstenediones and 7-substituted 4,6-androstadiene-3,17-diones.

Conformational sensitivity of beta-93 cysteine SH to ligation of hemoglobin observed by FT-IR spectroscopy.

The SH vibrational absorption of cysteine F9(beta-93) in concentrated aqueous solutions of native liganded hemoglobin (human HbA, horse, and bovine) has been observed by use of Fourier transform infrared spectroscopy. The pattern of beta-93 SH absorption intensity is ligand dependent. In bovine hemoglobin derivatives the SH absorption intensity pattern is (carbonmonoxy)hemoglobin (HbCO) greater than oxyhemoglobin (HbO2) = cyanomethemoglobin (HbCN) much greater than aquomethemoglobin (metHb) and deoxyhemoglobin (deoxyHb).

Infrared spectroscopy of photodissociated carboxymyoglobin at low temperatures.

We have studied the infrared spectra of the bound and photodissociated states of Mb-12CO and Mb-13CO from 5.2 to 300 K. The absorbance peaks seen between 1800 and 2200 cm-1 correspond to CO stretching vibrations.