Therapeutic potential of placenta-derived stem cells cultivated on noggin-loaded nanochitosan/polypyrrole-alginate conductive scaffold to restore spinal cord injury.

Objective: Spinal cord injury (SCI) is a severe and permanent nerve damage condition that poses significant burdens on individuals and society. Various therapeutic approaches have been explored to mitigate the consequences of SCI. Tissue engineering and regenerative medicine have emerged as a promising avenue for addressing this issue.

Infantile Sinonasal Tract Myxomas with Orbital Involvement: Presentation of Two Cases and Comprehensive Literature Review.

Our aim is to present two cases of infantile sinonasal tract myxoma with orbital involvement and conduct a comprehensive literature review of the topic. We aim to provide a summary of the presentation of infantile sinonasal tract myxomas to effectively aid clinicians in considering this rare entity as a potential diagnosis. We present a case series and a retrospective review of the published literature in the English language.

Combined cancer immunotherapy based on targeting adenosine pathway and PD-1/PDL-1 axis.

Introduction: Cancer immunotherapy has revolutionized the field of oncology, offering new hope to patients with advanced malignancies. Tumor-induced immunosuppression limits the effectiveness of current immunotherapeutic strategies, such as PD-1/PDL-1 checkpoint inhibitors. Adenosine, a purine nucleoside molecule, is crucial to this immunosuppression because it stops T cells from activating and helps regulatory T cells grow.

Health-promoting lifestyle behaviors and its association with sociodemographic characteristics in hospital clinical staff.

Objective: The aim of this study was to determine hospital clinical staff' health-promoting lifestyle behaviors, and explore associations between nurse demographic factors and lifestyle behaviors.

Methods: This cross-sectional investigation focused on the clinical personnel employed at hospitals associated with Baqiyatullah University. A sample of 341 clinical staff of hospitals was collected using convenience sampling.

Deciphering the Molecular Complexity of Hepatocellular Carcinoma: Unveiling Novel Biomarkers and Therapeutic Targets Through Advanced Bioinformatics Analysis.

Background: Hepatocellular carcinoma (HCC) represents a primary liver tumor characterized by a bleak prognosis and elevated mortality rates, yet its precise molecular mechanisms have not been fully elucidated. This study uses advanced bioinformatics techniques to discern differentially expressed genes (DEGs) implicated in the pathogenesis of HCC. The primary objective is to discover novel biomarkers and potential therapeutic targets that can contribute to the advancement of HCC research.

18 F-FDG PET/CT in Pediatric ALK-Positive Histiocytosis With Isolated CNS Involvement.

An 11-year-old girl presented with focal impaired awareness seizures. MRI brain demonstrated a T2 hyperintense cortical lesion in the left temporal lobe with surrounding vasogenic edema. 18 F-FDG PET/CT was arranged to assess metabolic activity of the cerebral lesion, to screen the whole body for other metabolically active lesions, and to assist biopsy planning.

LIRRN: Location-Independent Relative Radiometric Normalization of Bitemporal Remote-Sensing Images.

Relative radiometric normalization (RRN) is a critical pre-processing step that enables accurate comparisons of multitemporal remote-sensing (RS) images through unsupervised change detection. Although existing RRN methods generally have promising results in most cases, their effectiveness depends on specific conditions, especially in scenarios with land cover/land use (LULC) in image pairs in different locations. These methods often overlook these complexities, potentially introducing biases to RRN results, mainly because of the use of spatially aligned pseudo-invariant features (PIFs) for modeling.

Effects of hyperbaric oxygen therapy on autistic behaviors and gene expression in valproic acid-exposed rats.

Introduction: Autism is a complex neurodevelopmental condition characterized by deficits in social interaction, communication, and restricted repetitive behaviors. Hyperbaric oxygen therapy (HBOT) has emerged as a potential treatment for autism, although its effects on behavior and gene expression are not well understood. The gene, known for its involvement in encoding a glutamate receptor subunit crucial for neuron communication and associated with autism, was a focus of this study.

Mapping groundwater potential zone in the subarnarekha basin, India, using a novel hybrid multi-criteria approach in Google earth Engine.

Assessing groundwater potential for sustainable resource management is critically important. In addressing this concern, this study aims to advance the field by developing an innovative approach for Groundwater potential zone (GWPZ) mapping using advanced techniques, such as FuzzyAHP, FuzzyDEMATEL, and Logistic regression (LR) models. GWPZ was carried out by integrating various primary factors, such as hydrologic, soil permeability, morphometric, terrain distribution, and anthropogenic influences, incorporating twenty-seven individual criteria using multi-criteria decision models along with a hybrid approach for the Subarnarekha River basin, India, in Google earth engine (GEE).

Disgust-reduction evaluative conditioning (DREC) and brain stimulation in patients with contamination-based obsessive-compulsive disorder: a protocol for a randomized control trial.

Background: The negative emotional valence of a stimulus can be altered if paired with a pleasant stimulus, a phenomenon referred to as evaluative conditioning. Disgust, as a central emotion in obsessive-compulsive disorder (OCD), particularly in the contamination subtype, may be an appropriate target for such a method. We know that disgust processing and OCD pathophysiology share in some brain areas, including the orbitofrontal cortex, as the neuromodulation techniques targeted in this area have been able to decrease OCD symptoms.

Tumor suppressor p73 induces apoptosis of murine peritoneal cell after exposure to hydatid cyst antigens; a possibly survival mechanism of cystic echinococcosis in vivo mice model.

Cystic echinococcosis (CE) is a life-threatening helminthic disease caused by the Echinococcus granulosus sensulato complex. Previous evidence indicates that the host's innate immune responses against CE can combat and regulate the growth rate and mortality of hydatid cyst in the host's internal organs. However, the survival mechanisms of CE are not yet fully elucidated in the human body.

Behavioral and electrophysiological (ECoG) effects of haplophyllum robustum and TRPA1 antagonist in adult male wistar rats.

This article aimed to investigate the effects of Haplophyllum robustum hydroalcoholic extract on animals' behavioral and electrocorticographic changes. This plant is mainly found in Turkey, Iran, and Central Asia, and is reported to have convulsive effects. In this article, we worked on the effects of its hydroalcoholic extract on electrocorticography (ECoG), along with changes induced by intracerebroventricular administration of GABA antagonists.

Effect of stress on spatial working memory and EEG signal dynamics in the follicular and luteal phases of the menstrual cycle in young single girls.

Aim: Women undergo behavioral changes during the menstrual cycle. This study aimed to investigate the effect of estradiol (Es) on stress and effect of stress on spatial working memory (WM) and also to investigate electroencephalogram (EEG) signal's dynamics in the early and late follicular (EF and LF) and luteal (LU) phases of unmarried girls' menstrual cycle.

Methods: Stress was induced by presentation of a short (3 min) movie clip.

Validation of a tool for determining the clinical utility of stillbirth investigations.

Background: Up to 20% of all stillbirths and 45% of term stillbirths are currently classified as unexplained. Many of these stillbirths do not undergo currently recommended investigations. This may leave questions unanswered and not identify stillbirths with a recurrence risk in subsequent pregnancies.

Overview of Apoptosis, Autophagy, and Inflammatory Processes in Infected Cells.

() is an obligate intracellular parasite. During the parasitic invasion, creates a parasitophorous vacuole, which enables the modulation of cell functions, allowing its replication and host infection. It has effective strategies to escape the immune response and reach privileged immune sites and remain inactive in a controlled environment in tissue cysts.

Current Status and Future Forecast of Short-lived Climate-Forced Ozone in Tehran, Iran, derived from Ground-Based and Satellite Observations.

In this study, the distribution and alterations of ozone concentrations in Tehran, Iran, in 2021 were investigated. The impacts of precursors (i.e.

Extraction of alprazolam in biological samples using the dispersive solid-phase method with nanographene oxide grafted with α-pyridylamine.

An effective adsorbent was synthesised from nanographene oxide for the removal of the alprazolam drug from the water sample solution. The dispersive solid-phase extraction method was used with α-pyridylamine grafted nanographene oxide to extract and analyse little amounts of alprazolam in biological materials. Before beginning the experimental analysis process, it is critical to use a simple and accessible sample preparation approach.

Protective effect of Toll-like receptor 4 antagonist on inflammation, EEG, and memory changes following febrile seizure in Wistar rats.

Neuroinflammation and fever are the main triggers in febrile seizures (FS). Focusing on inflammatory pathways and anti-inflammatory drugs could compensate for the limitations of existing medications. The aim of this study is to evaluate the neuroprotective effect of specific antagonizing Toll-like receptor 4 (TLR4), as a prominent inflammatory axis, on the consequences of FS and adulthood using animal models.

Fabrication of superparamagnetic adsorbent based on layered double hydroxide as effective nanoadsorbent for removal of Sb (III) from water samples.

In this study, the superparamagnetic adsorbent as Fe@Mg-Al LDH was synthesised by different methods with two steps for the removal of heavy metal ions from water samples. An easy, practical, economical, and replicable method was introduced to remove water contaminants, including heavy ions from aquatic environments. Moreover, the structure of superparamagnetic adsorbent was investigated by various methods including Fourier transform infrared spectroscopy, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, and vibrating sample magnetometer.