Publications by authors named "Moghadami M"

Background: COVID-19 vaccination uptake is associated with demographic characteristics such as age, sex, and ethnicity-race in the United States (U.S.).

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Fungal infections are serious complications after solid organ transplantation, with high mortality and morbidity. Given the importance of the local epidemiological data and also extensive prophylactic regimens in solid organ transplant (SOT) recipients, this study aimed to investigate the clinical characteristics and resistance patterns of yeast isolates in SOT recipients at a main referral transplant center in Iran. Of the 275 recipients enrolled, 22 (8%) had at least one positive yeast culture at a median of 5 days after transplantation.

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Article Synopsis
  • - The study evaluated the immune response to COVID-19 in 30 patients, comparing those receiving convalescent plasma to a control group receiving normal plasma, using various measurement methods over several days post-infusion.
  • - Results indicated that convalescent plasma infusion resulted in lower levels of certain immune receptors (TLR7/8, PD-1, and CTLA-4) and increased levels of adaptive immune transcription factors (Tbet, RORγ3, Foxp3) compared to the control group.
  • - Additionally, the infusion led to a significant decrease in viral load and specific cytokines, suggesting that convalescent plasma can effectively modulate the immune response, warranting further investigation for confirmation.
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Background: Age, race, ethnicity, and sex are important determinants of coronavirus disease of 2019 (COVID-19) outcomes. Older adults (65 years and older) are at the highest risk of COVID-19 morbidity and mortality. Analyzing their vaccine uptake by subclassifying demographics is rare and can assist vaccination policies.

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Purpose: We applied machine learning to study associations between regional body fat distribution and diabetes mellitus in a population of community adults in order to investigate the predictive capability. We retrospectively analyzed a subset of data from the published Fasa cohort study using individual standard classifiers as well as ensemble learning algorithms.

Methods: We measured segmental body composition using the Tanita Analyzer BC-418 MA (Tanita Corp, Japan).

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  • * Conducted from April 2020 to February 2021, it analyzed 30,546 PCR tests, finding a 61.94% positivity rate and a subsequent low occurrence of reinfection (1.81% of total HCWs) after a 90-day period.
  • * The findings suggest that HCWs have a strong estimated immunity against recurring COVID-19 infections, with a 94.8% protection rate post-infection, indicating that serious cases of reinfection or relapse are uncommon in this group.
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Background And Aims: Faculty members confront a variety of obstacles over time, the most recent of which is the coronavirus disease 2019 pandemic, which may increase their vulnerability to burnout (BO). This study aims to examine BO in medical school faculties, as well as the factors that lead to BO and well-being in them.

Methods: This cross-sectional study was conducted in 2021 using online questionnaires completed by 222 faculty members of a medical university in Iran.

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  • The study addresses asymptomatic malaria within a specific malaria elimination program, emphasizing the need for reliable detection methods for both symptomatic and asymptomatic cases.
  • A total of 246 randomly selected individuals aged 4-60 were tested using various techniques, with a focus on those showing no symptoms and excluding recent antimalarial users.
  • The results showed no cases of asymptomatic malaria, indicating successful implementation of the malaria elimination program and highlighting the effectiveness of the local malaria surveillance system.
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  • * Participants were randomly assigned to receive either the 5 µg vaccine or a placebo, with results showing a 50.2% efficacy against symptomatic COVID-19 and higher rates against severe and critical cases.
  • * Safety data indicated that a significant number of adverse events were reported, but no deaths occurred in the vaccinated group, compared to two deaths in the placebo group.
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  • - The study aimed to validate an adapted Persian version of the Clinical Learning Evaluation Questionnaire (CLEQ) for assessing the clinical learning environment in medical students during their clinical rotations.
  • - A total of 200 students completed the 18-item questionnaire, which underwent a rigorous translation process, and data analysis showed strong validity and internal consistency, with Cronbach's alpha values indicating reliability.
  • - The findings suggest that the Persian CLEQ effectively measures transcultural adaptability in clinical education, and future research is recommended to explore both English versions of the CLEQ across different educational contexts.
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  • Global real-time monitoring of SARS-CoV-2 variants is essential for controlling COVID-19, leading to the development of a Sanger-based platform for variant tracking in low-resource labs.
  • The study utilized nested RT-PCR and Sanger sequencing on 1,028 samples, achieving high concordance with whole genome sequencing for mutation detection and lineage assignment.
  • The new method is effective for tracking variants of concern like Delta and Alpha, making it a viable option for countries with limited resources to monitor SARS-CoV-2 variants efficiently.
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  • The study analyzed the genetic diversity of SARS-CoV-2 in Iran over one year, following two independent viral introductions during the early outbreak phase.
  • Researchers sequenced 319 whole genomes between March 2020 and May 2021 to monitor the circulating viral lineages.
  • Results showed that different SARS-CoV-2 clades dominated various waves of infection, with the Delta variant emerging as a crucial factor in the fifth wave, highlighting significant mutations in key lineages.
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BackgroundImmunocompromised patients have lower seroconversion rate in response to COVID-19 vaccination. The aim of this study is to evaluate the humoral immune response with short-term clinical outcomes in solid organ transplant recipients vaccinated with SARS-CoV-2 vaccine (BBIBP-CorV; Sinopharm).MethodsThis prospective cohort was conducted from March to December 2021 in Abu Ali Sina hospital, Iran.

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There are several treatment protocols for acute viral hepatitis, and it is critical to recognize acute hepatitis in its earliest stages. Public health measures to control these infections also rely on rapid and accurate diagnosis. The diagnosis of viral hepatitis remains expensive, and there is no adequate public health infrastructure, while the virus is not well-controlled.

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Chronic forms of morbidity, including mental disorders and hypertension, play a dominant role in determining a disease load in the developing world. This article investigates the associations between the diagnoses of primary hypertension and generalized anxiety disorder (GAD) and the severity of GAD in individuals with primary hypertension. The association of GAD and age, sex, marriage, education level, income, chronic medical conditions, family history of mental disorders, adverse life events, and hypertension was assessed in 470 patients with the diagnosis of primary hypertension.

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Currently, there is controversy regarding the treatment of pregnant patients with mild hypertension (blood pressure 140-159/90-109 mm Hg). While guidelines do not recommend this treatment, results from recent clinical trials are supportive of the treatment. This meta-analysis aimed to clarify if active treatment of mild hypertension during pregnancy results in better maternal and fetal outcomes.

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Introduction: Critical appraisal skills are presumed to perform a principal part in evidence-based health education and practice methods. This study aimed to design an educational intervention around critical appraisal in this context, evaluate the efficacy of the teaching methods, and investigate critical appraisal skills training to undergraduate medical students.

Methods: In this prospective Randomized Control Trial (RCT), 256 sixth-year undergraduate medical students from Shiraz University of Medical Science, Shiraz, Iran, participated.

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Introduction: Households' dietary habits are affected by their environment and socioeconomic status (SES). This study aims to investigate eating behaviors and determine the factors affecting nutritional status in households in Fars Province in 2018.

Method: In this cross-sectional study, urban and rural households were selected using the multistage sampling method.

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COVID-19 patients in critical conditions are hospitalized and treated with various protocols including antiviral drugs, which have been updated repeatedly. This study was aimed to analyze the demographics, costs, and outcomes of drug regimens in COVID-19 patients hospitalized in "Ali Asghar" hospital, affiliated with Shiraz University of Medical Sciences, from March 2019 to December 2020 as a retrospective study, approved by the ethics committee of Shiraz University of Medical Sciences (IR.SUMS.

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Background: Mucormycosis infection is a complication seen in some coronavirus disease 2019 (COVID-19) patients. This study compares the characteristics of mucormycosis infection between COVID-19 and non-COVID-19 patients.

Methods: This retrospective cohort comprised 87 patients with mucormycosis divided into two groups.

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Purpose Of Review: Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) can increase the susceptibility of individuals to contracting mucormycosis through several mechanisms. Nowadays, coronavirus disease (COVID-19)-associated mucormycosis (CAM) is a serious public health concern, particularly in developing countries. This meta-analysis aims to identify the risk factors that affect the mortality rate of patients with CAM.

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Background: There are some concerns about the effectiveness of the inactivated and vector-based vaccines against severe acute respiratory syndrome coronavirus 2 in real-world settings with the emergence of new mutations, especially variants of concern. Data derived from administrative repositories during mass vaccination campaigns or programs are of interest to study vaccine effectiveness.

Methods: Using 4-repository administrative data linkage, we conducted a historical cohort study on a target population of 1 882 148 inhabitants aged at least 18 years residing in southern Iran.

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Aside from typical pneumonia, the coronavirus disease 2019 (COVID-19) has shown several extra-pulmonary manifestations. This study was done on a 66-year-old male patient who concomitantly had endogenous endophthalmitis and left ventricular thrombosis one month after being hospitalized due to COVID-19.

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