Fabrication and characterization of chitosan-based bionanocomposite coating reinforced with TiO nanoparticles and carbon quantum dots for enhanced antimicrobial efficacy.

Polymer-based nanocomposite coatings that are enhanced with nanoparticles have gained recognition as effective materials for antibacterial purposes, providing improved durability and biocidal effectiveness. This research introduces an innovative chitosan-based polymer nanocomposite, enhanced with titanium oxide nanopowders and carbon quantum dots. The material was synthesized via the sol-gel process and applied to 316L stainless steel through dip-coating.

Comparative morphological, physiological, and biochemical traits in sensitive and tolerant maize genotypes in response to salinity and pb stress.

Salinity and lead are two important abiotic stresses that limit crop growth and yield. In this study, we assayed the effect of these stresses on tolerant and sensitive maize genotypes. Four-week-old maize plants were treated with 250 mM sodium chloride (NaCl) and 250 µM lead (Pb).

RibMR - A Mixed Reality Visualization System for Rib Fracture Localization in Surgical Stabilization of Rib Fractures: Phantom, Preclinical, and Clinical Studies.

In surgical stabilization of rib fractures (SSRF), the current standard relies on preoperative CT imaging and often incorporates ultrasound (US) imaging. As an alternative, mixed reality (MR) technology holds promise for improving rib fracture localization. This study presents an MR-based visualization system designed for SSRF in a clinical setting.

Comparison of the effectiveness of self-care educational program using animation and role-playing on quality of life in adolescents with type 1 diabetes.

Background: Type 1 diabetes is a chronic disease and the number of Adolescents diagnosed with it, is at an increase. Self-care education can reduce the complications of this disease. Therefore, this research was conducted to determine and compare the effectiveness of self-care educational programs, using animation and role-playing on quality of life in Adolescents with type 1 diabetes.

Identification and characterization of the Quinoa AP2/ERF gene family and their expression patterns in response to salt stress.

The APETALA2/ETHYLENE RESPONSIVE FACTOR (AP2/ERF) transcription factors play crucial roles in plant growth, development, and responses to biotic and abiotic stresses. This study was performed to comprehensively identify and characterize the AP2/ERF gene family in quinoa (Chenopodium quinoa Willd.), a highly resilient pseudocereal crop known for its salinity tolerance.

Association between the dietary inflammatory index and risk of lung cancer: a multi-centered case-control study.

Purpose: Dietary factors might contribute to the risk of lung cancer by increasing the concentration of inflammatory markers. The literature-derived Dietary Inflammatory Index (DII) has been established to evaluate the inflammatory potential of diet correlated with inflammatory markers. The association between DII scores and the risk of lung cancer has been conflicting.

Effects of intravenous tranexamic acid on bleeding during burn surgery: A double-blinded randomized clinical trial.

Blood loss during burn surgery significantly contributes to morbidity and mortality. Tranexamic acid (TXA), an antifibrinolytic agent, is hypothesized to reduce intraoperative bleeding. This double-blinded, randomized clinical trial aimed to assess the efficacy of systemic TXA in severe burn patients (total body surface area [TBSA] > 20 %) undergoing surgery.

Anatomical assessment of the Kambin's triangle for percutaneous posterolateral transforaminal endoscopic surgery of lumbar intervertebral discs: a magnetic resonance imaging based study.

The aim of the present study was to utilize magnetic resonance imaging (MRI) as a noninvasive tool for evaluation of the Kambin's triangle safe zone. Lumbar MRIs of 67 healthy subjects were analyzed. On the coronal plane, the distance from the superior endplate to the nerve root exiting from the dura (distance a), the distance from the lateral aspect of the dura to the medial aspect of the nerve root (distance b), and the angle between the nerve root and plane of the corresponding disc (angle α) was measured.

Cesarean scar niche: comparison of transvaginal ultrasound findings and uterine tissue samples after hysterectomy.

Background: The cesarean scar niche, a consequence of incomplete wound healing, can lead to gynecological complications and affect future pregnancies. While internal niches have been well-studied, external and bidirectional niches are also important.

Objective: We aimed to conduct a comparative analysis of the prevalence and measurements of different types of niches.

Relationship between mutations in severe hemophilia A and risk of inhibitor development: A large single-center study.

Background: One of the major problems for patients with severe hemophilia A (HA) is the development of neutralizing antibodies against factor VIII. This study aimed to analyze the molecular and clinical profiles of patients with severe HA and to determine if certain genetic variants predispose to inhibitor development in these patients.

Methods: A single-center study was conducted among patients with severe HA between March 20, 2000, and June 31, 2023.

Transitions in lung microbiota landscape associate with distinct patterns of pneumonia progression.

The precise microbial determinants driving clinical outcomes in severe pneumonia are unknown. Competing ecological forces produce dynamic microbiota states in health; infection and treatment effects on microbiota state must be defined to improve pneumonia therapy. Here, we leverage our unique clinical setting, which includes systematic and serial bronchoscopic sampling in patients with suspected pneumonia, to determine lung microbial ecosystem dynamics throughout pneumonia therapy.

Chitosan/MgO NPs/CQDs bionanocomposite coating: Fabrication, characterization and determination of antimicrobial efficacy.

The development of new polymer nanocomposites or antibacterial coatings is crucial in combating drug-resistant infections, particularly bacterial infections. In this study, a new chitosan polymer based nanocomposite reinforced with magnesium oxide nanopowders and carbon quantum dots was fabricated by sol-gel technique and coated on 316 L stainless steel. In order to gaining the optimal amount of components to achieve the maximum antibacterial properties, the effect of concentration of nanocomposite components on its antibacterial properties was investigated.

Genotype-phenotype analyses of Iranian patients with hemophilia B (Leyden -) and hemophilia B (Leyden +): A single-center study.

Background: There is a high prevalence of inherited bleeding disorders in Iran, such as hemophilia A (HA) and hemophilia B (HB). This study aimed to analyze the molecular and clinical profiles of patients with HB.

Methods: A single-center study was conducted among patients with severe HB between March 20, 2000, and June 31, 2023.

Structure-guided design and cloning of peptide inhibitors targeting CDK9/cyclin T1 protein-protein interaction.

CDK9 (cyclin-dependent kinase 9) plays a significant role in numerous pathological conditions, such as HIV-1 infection and cancer. The interaction between CDK9 and cyclin T1 is crucial for maintaining the kinase's active state. Therefore, targeting this protein-protein interaction offers a promising strategy for inhibiting CDK9.

A systematic review of diagnostic and interventional techniques in non-occlusive hepatic artery hypoperfusion syndrome.

Objective: This systematic review aims to elucidate the diagnostic capabilities of imaging techniques in identifying Non-Occlusive Hepatic Artery Hypoperfusion Syndrome (NOHAH) and to evaluate the efficacy and outcomes of splenic artery embolization (SAE), including the choice and placement of embolic agents.

Materials And Methods: A comprehensive literature search was conducted using PubMed, CINAHL, and Scopus databases, adhering to PRISMA guidelines. Fifteen studies encompassing 240 patients treated with embolization (using coils or Amplatzer Vascular Plugs (AVP)) were analyzed.

Synthesis, characterization, and investigation of antibacterial activity of Novel CMC/CuO NPs/CQDs bionanocomposite coating.

In recent decades, healthcare-associated infections (HAIs) have become a common problem in healthcare facilities such as hospitals. As a result, researchers are currently developing nanocomposite coatings that are strengthened with antibacterial nanoparticles. In this research, a novel antibacterial bionanocomposite coating based on carboxymethyl cellulose polymer/copper oxide nanoparticles/carbon quantum dots was coated on medical grade 316 stainless steel by sol-gel dip-coating method.

Efficient Expression of Functionally Active Aflibercept with Designed N-glycans.

Aflibercept is a therapeutic recombinant fusion protein comprising extracellular domains of human vascular endothelial growth factor receptors (VEGFRs) and IgG1-Fc. It is a highly glycosylated protein with five N-glycosylation sites that might impact it structurally and/or functionally. Aflibercept is produced in mammalian cells and exhibits large glycan heterogeneity, which hampers glycan-associated investigations.

RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis.

Background: Pterygium, characterized by the abnormal proliferation of epithelial cells, matrix remodeling, vascularization, and lesion migration, is a prevalent ocular surface disease involving the growth of fibrovascular tissue on the cornea. Despite the unclear underlying causes of pterygium, numerous investigations have indicated the involvement of cell death pathways in the regulation of cell cycle dynamics. Consequently, the objective of this study was to assess the expression levels of necroptosis markers in individuals diagnosed with pterygium, aiming to shed light on the potential role of necroptosis in the pathogenesis of this condition.

Molecular and clinical profile of rare bleeding disorders: A single-center retrospective study.

Introduction: Due to their low frequency, there is little information on the molecular pathologies of rare bleeding disorders (RBD). Therefore, this study aimed to analyze the molecular and clinical profiles of patients with RBD.

Methods: A retrospective single-center study was conducted among patients with factor (F) II, FVII, FX, and FXIII deficiencies between March 20, 2000, and June 31, 2023.

Revisiting echocardiographic features of prosthetic heart valves: the necessity of correct differentiation of mono-leaflet vs. bileaflet mechanical heart valves in a case report.

Background: Mechanical heart valve replacement is a standard treatment for severe valvular disorders. The use of mono-leaflet valves has decreased recently. Recognizing the echocardiographic features of mono-leaflet and bileaflet valves is crucial for accurate complication diagnosis and proper management.

Assessment of Cementitious Composites for High-Temperature Geothermal Wells.

High-temperature (HT) geothermal wells can provide green power 24 hours a day, 7 days a week. Under harsh environmental and operational conditions, the long-term durability requirements of such wells require special cementitious composites for well construction. This paper reports a comprehensive assessment of geothermal cement composites in cyclic pressure function laboratory tests and field exposures in an HT geothermal well (300-350 °C), as well as a numerical model to complement the experimental results.

Evaluation of the expression level of microRNA-21, microRNA-15a, microRNA-372 in human follicular fluid stem cells-derived oocyte-like cells (OLCs).

Objective: Today, researchers have succeeded in achieving oocyte-like cells through the in vitro differentiation of stem cells. MicroRNAs are key regulators of oocyte development. In this study we decided to evaluate the expression pattern of microRNA-21, microRNA-15a, and microRNA-372 in oocyte-like cells, to determine the maturation stage of oocyte-like cells.