Blood pressure in Danish children during general anaesthesia: Hypotension in a paediatric population observational (HIPPO) study.

Background: In Denmark, thousands of infants and children require general anaesthesia annually. Hypotension during general anaesthesia might reduce cerebral blood flow and oxygen delivery to the brain. Safe lower limits of blood pressure are ill defined.

Pharmacokinetics of an intravenous bolus dose of clonidine in children undergoing surgery.

Background: Clonidine is used off-label in children but only limited pediatric pharmacokinetic data are available for intravenously administered clonidine.

Objectives: To determine pharmacokinetic parameter estimates of clonidine in healthy children undergoing surgery and to investigate age-related differences. Furthermore, to investigate possible pharmacokinetic differences of clonidine between this group of children and a cohort with cardiac diseases.

Intraoperative clonidine for prevention of postoperative agitation in children anaesthetised with sevoflurane (PREVENT AGITATION): a randomised, placebo-controlled, double-blind trial.

Background: Postoperative agitation is a frequent and stressful condition for a child, their family, and their health-care providers, and prevention would be of benefit. We aimed to assess the effects of intravenous clonidine administered intraoperatively on the incidence of postoperative agitation, pain, and adverse events.

Methods: We did this randomised, placebo-controlled, double-blind trial (PREVENT AGITATION) at one tertiary-level hospital and two urban-district hospitals in Denmark.

Effect of clonidine to prevent agitation in children after sevoflurane anaesthesia: a randomised placebo controlled multicentre trial.

Introduction: Post-operative agitation (PA) is a common problem (20-70%) in children anaesthetised with sevoflur-ane. Clonidine is widely used off-label in children for several indications, including PA, but the current level of evidence is limited. Our aim is to investigate the impact of prophylactic intravenous (IV) clonidine administered at the end of surgery on the incidence and degree of PA.

Treatment of critical illness polyneuropathy and/or myopathy - a systematic review.

Introduction: The objective was to search the literature with a view to providing a general description of critical illness myopathy/polyneuropathy (CIM/CIP), including its genesis and prevention. Furthermore, it was our aim to determine whether new treatments have occurred in the past five years.

Material And Methods: PubMed, Cinahl and Swedmed+ were searched using the terms CIM, CIP and intensive care.

[Communication in a hospital by means of a standardised method].

We know from the aviation industry and several studies, that efficient and safe communication is extremely important, especially in emergencies. This study evaluated the use of the "identification, situation, background, analysis and recommendation" (ISBAR) checklist, when doctors from the department of anaesthesiology were called for assistance. After the initial evaluation, a short education session (less than 15 minutes) was carried out.

[Paranoid schizophrenic patient with unstable spinal fracture].

The misdiagnosis of somatic illness in the psychiatric population can have grave consequences. Somatic symptoms are easily overseen or misinterpreted and a careful history and examination is essential when approaching this group of patients. We report a case of a patient with a history of paranoid schizophrenia, who had her somatic symptoms misinterpreted as being of psychiatric origin.