Publications by authors named "Moemi Oda"
Article Synopsis
- The study focuses on kidney podocytes and how their function relies on the actin cytoskeleton regulated by Rho small GTPases, highlighting that podocyte dysfunction is linked to kidney diseases and proteinuria.
- FilGAP, a protein that activates Rho small GTPase Rac1, is essential for maintaining podocyte structure, as its depletion leads to a loss of actin stress fibers and reduced cell adhesion.
- The research demonstrates that FilGAP helps podocytes form necessary structures and attachments to the extracellular matrix by inhibiting Rac1 and PAK1 signaling pathways, suggesting its critical role in preventing kidney-related pathologies.
