Publications by authors named "Moeckel M"
Design of experiments (DOE) is an established method to allocate resources for efficient parameter space exploration. Model based active learning (AL) data sampling strategies have shown potential for further optimization. This paper introduces a workflow for conducting DOE comparative studies using automated machine learning.
View Article and Find Full Text PDFMulticlass classification of Autism Spectrum Disorder, attention deficit hyperactivity disorder, and typically developed individuals using fMRI functional connectivity analysis.
PLoS One
October 2024
Article Synopsis
- Neurodevelopmental conditions like Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) often have overlapping symptoms, complicating accurate diagnosis and treatment.
- This study uses advanced machine learning to analyze fMRI data from 120 subjects, achieving high accuracy in differentiating between ASD, ADHD, and typically developed individuals, with an ROC curve area nearing 98%.
- The research identifies unique brain connectivity patterns for each condition, aligning with clinical observations, and suggests that machine learning could improve diagnostic processes and clinical decision-making in neurodevelopmental disorders.
Importance: Boarding in the emergency department (ED) is a critical indicator of quality of care for hospitals. It is defined as the time between the admission decision and departure from the ED. As a result of boarding, patients stay in the ED until inpatient beds are available; moreover, boarding is associated with various adverse events.
View Article and Find Full Text PDFAtherosclerotic renal artery stenosis (ARAS) is a predictor of increased morbidity and mortality. However, whether ARAS itself accelerates the arteriosclerotic process or whether ARAS is solely the consequence of atherosclerosis is unclear. We imaged renal arteries of 1561 hypertensive patients undergoing coronary angiography and followed this cohort for 9 years (range, 2.
View Article and Find Full Text PDFArticle Synopsis
- Serum mid-regional pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MR-proADM) are new biomarkers helpful for diagnosing acute heart failure (AHF).
- Clinical factors like renal failure and obesity can affect the effectiveness of these biomarkers, but diabetes seems not to impact their ability to diagnose AHF or predict 90-day mortality.
- However, in patients without AHF, higher levels of MR-proADM were linked to a diagnosis of diabetes.
Background: Concerns persist regarding the risk of stent thrombosis in the setting of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction.
Methods And Results: The Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial included 3602 patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention who were randomized to heparin plus a glycoprotein IIb/IIIa inhibitor (GPI) (n=1802) versus bivalirudin monotherapy (n=1800). Stents were implanted in 3202 patients, including 2261 who received drug-eluting stents and 861 who received only bare metal stents.
Motivated by recent experiments in ultracold atomic gases that explore the nonequilibrium dynamics of interacting quantum many-body systems, we investigate the opposite limit of Landau's Fermi-liquid paradigm: We study a Hubbard model with a sudden interaction quench, that is, the interaction is switched on at time t=0. Using the flow equation method, we are able to study the real time dynamics for weak interaction U in a systematic expansion and find three clearly separated time regimes: (i) An initial buildup of correlations where the quasiparticles are formed. (ii) An intermediate quasi-steady regime resembling a zero temperature Fermi liquid with a nonequilibrium quasiparticle distribution function.
View Article and Find Full Text PDFWe prospectively evaluated the learning curve (LC) for laparoscopic urethrovesical anastomosis (L-UVA) in an operator-training model and program using an innovative simplified pelvic-trainer model. Over a period of 12 months, 30 LRP were performed by one urologist skilled in open surgery but inexperienced in laparoscopy. During the first 15 procedures no systematic training was done.
View Article and Find Full Text PDFObjective: We prospectively evaluated the learning curve (LC) of laparoscopic radical prostatectomy (L-RPE) regarding the improvements in operative times (OT) and technical difficulty in one-operator-practice as it compares with open RPE.
Methods: Over 18 months, 50 L-RPE were performed by an inexperienced surgeon in laparoscopy but skilled in open surgery. Difficulty scores were obtained at the completion of each L-RPE comparing L-RPE to open RPE.
Objectives: To compare the impact of radical nephrectomy and nephron-sparing surgery (NSS) for localized renal cell carcinoma on quality of life (QOL).
Methods: Retrospectively, 357 patients who had undergone NSS (n = 158) or radical nephrectomy (n = 199) for localized renal cell carcinoma completed postal questionnaires, including measures of QOL with validated instruments (SF-36, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 [EORTC QLQ-C30]), the impact of the stress of cancer, fear of recurrence, and worry about having fewer than two normal kidneys. A subset of 51 patients diagnosed after 2000 were followed up prospectively for at least 1 year.