Publications by authors named "Moe Tanaka"
Dupilumab Efficacy in Relation to Changes in Club Cell Secretory Protein 16.
Ann Allergy Asthma Immunol
March 2025
Background: Although the performance of dupilumab in severe asthma has been evaluated, the detailed mechanism underlying its effect remains unclear.
Objective: We analyzed the effect of dupilumab on serum club cell secretory protein 16 (CC16).
Methods: Twenty-five patients who were administered dupilumab and underwent computed tomography (CT) before and approximately 4 months after the introduction of dupilumab were included.
Article Synopsis
- - Dysfunctional breathing (DB) is a commonly overlooked issue in asthma patients in Japan, prompting a study to understand its clinical characteristics through a questionnaire survey conducted in three regions (Niigata, Kumamoto, and Tokyo) between September and November 2021.
- - The survey involved 2,087 asthma patients, with 217 classified as having DB based on their Nijmegen questionnaire scores; significant differences emerged between DB and non-DB groups concerning factors like sex, disease duration, asthma control, and mental health.
- - Results indicated that asthma patients with DB often experienced symptoms of depression and had poorly controlled asthma, highlighting a need for larger studies to further explore these findings and potential interventions.
Article Synopsis
- Induced pluripotent stem (iPS) cells, despite their promise for regenerative medicine, have tumorigenic properties, necessitating the selective elimination of malignant cells during product manufacturing.* -
- In the study, hybrid liposomes (HL) were used to selectively target and eliminate human hepatocellular carcinoma (HuH-7) cells from a mixed culture with normal human fetal hepatocytes (Hc cells), preserving the viability of Hc cells.* -
- The findings indicate that HL can effectively suppress the tumorigenicity of HuH-7 cells, showing potential for improving the safety of regenerative medicine products by keeping normal cells unharmed.*
Free radical-mediated lipid peroxidation (LPO) induces the formation of numerous lipid radicals, which contribute to the development of several oxidative diseases. To understand the mechanism of LPO in biological systems and the significance of these radicals, identifying the structures of individual lipid radicals is imperative. In this study, we developed an analytical method based on liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) and a profluorescent nitroxide probe, -(1-oxyl-2,2,6-trimethyl-6-pentylpiperidin-4-yl)-3-(5,5-difluoro-1,3-dimethyl-3,5-5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-7-yl)propanamide (BDP-Pen), for the detailed structural analysis of lipid radicals.
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- Severe fever with thrombocytopenia syndrome (SFTS) and Japanese spotted fever (JSF) are tick-borne diseases posing rising public health challenges in Japan and East Asia.
- A study analyzed data from 23 SFTS and 38 JSF patients to identify clinical characteristics useful for differentiating the two diseases, focusing on symptoms, exams, and lab findings.
- Key indicators to differentiate SFTS from JSF included leukopenia (WBC < 4000/μL) and altered mental status, while absence of skin rash also supported the diagnosis in suspected cases.
Ectopic soft tissue calcification (ESTC), a rare clinical condition, causes tissue and organ damage. It is associated with chronic renal failure, hyperparathyroidism, and malignant neoplasms, including multiple myeloma, and it is reportedly resistant to treatment. Here, we present the case of a 71-year-old male with multiple myeloma who had rapid ESTC in the lung.
View Article and Find Full Text PDFBackground: Human skin microorganisms have been associated with various skin diseases. However, most studies have focused on bacterial communities, and little is known about normally resident skin viruses such as the Polyomaviridae and their association with cutaneous disorders.
Methods: We investigated the infection levels of Merkel cell polyomavirus (MCPyV), human polyomavirus 6 (HPyV6), and human polyomavirus 7 (HPyV7), using triplet skin swabs collected from lesional and nonlesional skins of 86 Japanese patients with inflammatory skin diseases and mycosis fungoides, and from 149 healthy control individuals.
Background: Although Merkel cell polyomavirus (MCPyV) has the potential to cause Merkel cell carcinoma (MCC), it is also found in the normal skin of healthy individuals. However, the mechanism for transformation of MCPyV to an oncogenic form is unknown.
Objectives: To investigate the levels of MCPyV infection in the normal skin patients with MCC compared with those in a control cohort.
Background: Despite the oncogenic potential of Merkel cell polyomavirus (MCPyV), it has been found in the normal skin of healthy individuals; however, little is known about geographical variations in the ecology of MCPyV in this tissue.
Methods: This study included 284 Japanese participants. Sun-unexposed arm and sun-exposed forehead skin swab samples were obtained and analyzed for MCPyV infection, using quantitative polymerase chain reaction.
The enantiomer separation of five nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, ketoprofen (KP) and naproxen (NX), which are included in The Japanese Pharmacopoeia 16th edition (JP16), was investigated by employing four kinds of 3 μm reversed-phase chiral columns (AD-3R, AS-3R, OD-3R and OJ-3R). Except for KP, the enantiomers of four NSAIDs were successfully separated by one of the four columns. Among five NSAIDs, only NX has been used as a single enantiomer (S-form, active form) in the clinical field (JP16); therefore, optical purity testing method of NX is required for its quality evaluation.
View Article and Find Full Text PDFThe pronounced enhancement of the effective mass is the primary phenomenon associated with strongly correlated electrons. In the presence of local moments, the large effective mass is thought to arise from Kondo coupling, the interaction between itinerant and localized electrons. However, in d electron systems, the origin is not clear because of the competing Hund's rule coupling.
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