Publications by authors named "Modeste Sameza"

The present study was carried out to investigate the anti-inflammatory activity of a methanolic extract and fractions of stems. The crude extract was obtained by maceration of the powder in methanol and fractions by vacuum chromatography from the methanolic extract. To study the anti-inflammatory activity , red blood cell lysis inhibition assay and albumin denaturation inhibition were performed, while measurements of carrageenan-induced paw oedema and formalin-induced pain in albino mice were performed.

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Chemical investigation of the endophytic fungus, , isolated from healthy and asymptomatic common bean field crop, resulted in the isolation of a new alkene, ()-5-amino-5-(1,1,2-trihydroxybuta-1,3-dienyloxy)pentane-6,7,8,9-tetraol (), together with five known compounds (-). The structures of the compounds were elucidated by analysis of their spectroscopic data including 1 D, 2 D NMR, ESI-HRMS and literature data. The organic crude extract and the compound isolated from significantly (p ≤ 0.

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Article Synopsis
  • A new alkaloid, 8,9-dimethoxy-5-phenanthridin-6-one, along with two flavonoids, was isolated for the first time from a natural source.
  • The compounds were characterized using advanced NMR spectroscopy and mass spectrometry to determine their structures.
  • Some fractions showed strong antifungal activity against certain yeast strains, suggesting that the source may have potential for developing antifungal drugs.
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This investigation was aimed to evaluate the antimicrobial activities and involvement of extracellular lytic enzymes produced by four strains of Trichoderma in the inhibition of Pythium myriotylum. Antagonistic effects were tested by dual culture. Activities of lytic enzymes were evaluated from the filtrate of each strain after cultivation in selected media.

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  • The study examined the toxicity of aqueous extracts from Colocasia esculenta leaves infected by Phytophthora colocsiae in Wistar rats, assessing both acute and subacute effects.
  • Acute administration of doses up to 4000 mg/kg showed no immediate toxicity signs or mortality, suggesting a high LD50, while subacute treatment at 800 mg/kg in males led to symptoms like spiky hair, breathing issues, and death.
  • Significant changes in blood parameters and adverse effects on lung tissues were observed, indicating potential health risks at higher or repeated doses of the infected extract.
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The aim of this work was to evaluate the antimicrobial activities of leaves and epicarp of Citrus aurantifolia essential oil against Phytophthora colocasiae, the causative agent of taro leaf blight. Oils were extracted by hydrodistillation, and their chemical composition was determined by gas chromatography and gas chromatography coupled with mass spectrometry. Antimicrobial activities of oils were tested in vitro against mycelium growth and sporangium production.

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The free-radical scavenging activity of ethanolic and methanolic extracts of leaves, stems and roots of Annona muricata, Monodora tenuifolia, Uvaria comperei, Uvaria muricata and Xylopia africana was evaluated using DPPH and ORAC assays. Further, phytochemical analysis, total phenolic and total flavonoid contents were also determined. Moreover, the antifungal activity of extracts was studied.

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Iodine deficiency diseases (IDD) are a public health problem in many developing countries, such as Cameroon. They are often the consequence of insufficient iodine intake and/or the effect of thiocyanate in foods such as cassava; this chemical inhibits iodine fixation by the thyroid gland. One method of combatting these diseases is to counsel and encourage the consumptions of iodine-rich foods.

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