Risk factor for difficult cases at the comprehensive consultation services about medical, welfare and legal problems.

Unlabelled: It is very important to cooperate with interprofessional personnel is in order to establish the community-based integrated care system, but this is very difficult. We have held comprehensive consultation services regarding medical, welfare, and legal problems to support the community.

Objectives: This study aimed to identify the associations between background factors (such as medical conditions, intractable diseases, welfare problems, disabilities, economic difficulties, legal problems, elderly adults, children, and foreign persons) and difficult cases to provide more thorough consultation services.

Cervical-First Approach in Thoracoscopic Esophagectomy With Intraoperative Nerve Monitoring for an Esophageal Cancer Patient With Aberrant Right Subclavian Artery.

An aberrant right subclavian artery (ARSA) is a rare vascular anomaly accompanied by nonrecurrent inferior laryngeal nerve (NRILN). Here, we described the cervical-first approach in thoracoscopic esophagectomy for an esophageal cancer patient with ARSA using the intraoperative nerve monitoring (IONM) system. First, a left cervical procedure proceeded to expose the left vagus nerve to attach the APS electrode of the IONM system, and the left cervical paraesophageal lymph nodes was dissected separately.

Impact of the severe acute respiratory syndrome coronavirus 2 pandemic on the incidence of type 1 diabetes mellitus in children in Yamanashi, Japan.

It has been hypothesized that the biopsychosocial stress associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, in combination with the immunological effects of SARS-CoV-2 and pancreatic β-cell dysfunction, may contribute to the onset of type 1 diabetes (T1D) in children. In this study, we documented the incidences of T1D in Yamanashi Prefecture, Japan, from 1986 to 2018, and expanded the analysis to include cases from 2019 to 2022 to evaluate the potential influence of coronavirus disease 2019 (COVID-19) on T1D incidence. The COVID-19 pandemic period was defined as 2020 to 2022.

Brain regions associated with balance function assessed by the Berg Balance Scale in post-stroke patients.

[Purpose] To assess the neural fiber damage causing balance deficits in post-stroke patients. [Participants and Methods] Diffusion tensor imaging was conducted during the second week after stroke onset, and the Berg Balance Scale scores were recorded at discharge from our affiliated rehabilitation facility. The total score of the motor component of the Stroke Impairment Assessment Set and the Functional Independence Measure motor score were also documented.

Slowly progressive subtype of childhood-onset type 1 diabetes as a high-risk factor for end-stage renal disease: A cohort study in Japan.

Aim: To compare the incidence of end-stage renal disease (ESRD) between slowly progressive type 1 diabetes and acute-onset type 1 diabetes.

Methods: This cohort study enrolled all 521 patients with childhood-onset type 1 diabetes with the year of onset from 1959 to 1996 in Hokkaido Prefecture, Japan. We calculated the ESRD incidence rate per 100,000 person-years by sex, onset year, onset age, and type 1 diabetes subtype (slowly progressive or acute-onset).

Persistent SARS-CoV-2 infection resolved after B-cell recovery in a patient with follicular lymphoma treated with B-cell depletion therapy.

A 68-year-old woman with follicular lymphoma was treated with chemotherapy, including the anti-CD20 monoclonal antibody obinutuzumab, and achieved remission. A month after the administration of obinutuzumab, the patient contracted coronavirus disease 2019 (COVID-19), and various antiviral drugs were administered. However, the infection had not been eliminated.

Correction: Mortality in childhood-onset type 1 diabetes mellitus with onset between 1959 and 1996: A population-based study in Hokkaido, Japan.

[This corrects the article DOI: 10.1007/s13340-023-00688-0.].

Exotic Spin Excitations in a Polar Magnet VOSe_{2}O_{5}.

Magnetic resonance dynamics has been studied for a polar magnet VOSe_{2}O_{5}, which hosts several nontrivial magnetic phases including Néel-type skyrmion lattice (SkL). In both cycloidal and SkL spin states, two excitation modes active to oscillating magnetic field B_{ν}⊥c and one mode active to B_{ν}∥c are identified. The subsequent micromagnetic simulations well reproduce the observed selection rules and relative resonance frequencies, which allows the unambiguous assignment of the spin oscillation manner for each mode.

Confined antiskyrmion motion driven by electric current excitations.

Current-driven dynamics of topological spin textures, such as skyrmions and antiskyrmions, have garnered considerable attention in condensed matter physics and spintronics. As compared with skyrmions, the current-driven dynamics of their antiparticles - antiskyrmions - remain less explored due to the increased complexity of antiskyrmions. Here, we design and employ fabricated microdevices of a prototypical antiskyrmion host, (FeNiPd)P, to allow in situ current application with Lorentz transmission electron microscopy observations.

Interplay of co-cultured chimeric adipose and gingival tissues exacerbates inflammatory dysfunction relevant to periodontal and metabolic conditions.

Adipose tissue dysfunction is a key feature of metabolic syndrome, which increases the risk of periodontitis, an inflammatory disease induced by bacteria that affects the gingiva and other components of periodontal tissue. Recent studies indicate that molecules from inflamed periodontal tissue contribute to adipose tissue dysfunction. However, the cellular mechanisms and interactions between adipose tissue and gingiva driving the progression of metabolic and periodontal conditions remain unclear.

Trends in the market for drug delivery devices categorized as combination drugs and medical devices and regulatory challenges for autoinjectors in Japan.

Background: Although a variety of drug delivery devices have been launched in recent years, few studies have comprehensively investigated the market trends of combination drugs and medical devices approved or certified in Japan and the regulatory challenges related to their approval. Among the drug delivery devices, autoinjectors are more convenient than traditional prefilled syringes and are designed with safety features to prevent needlestick accidents, allowing self-injection by patients. Therefore, autoinjectors have been incorporated into the treatment of various diseases and have shown significant growth among drug delivery devices.

Extending the Lifetime of Frying Oil through Optimization of Fryer Cleaning.

With increases in consumer demand for fried foods in Japan over the last several decades, the consumption of frying oil has also steadily increased. Fryers used in restaurants to cook large quantities of food are typically cleaned using neutral kitchen detergents at the end of the day after removing the oil from the tank. However, significant amounts of debris can remain in the fryer after cleaning, possibly accelerating oil deterioration and thus reducing the quality of the fried foods.

Forelimb lameness caused by malignant peripheral nerve sheath tumors of the median nerve in a dog: a case report.

An 8-year-old Portuguese Water Dog presented with a 5-month history of left forelimb lameness. There was palmar pain. Ultrasonography revealed enlargement of the left median nerve.

The Effects of Adlay Tea Intake on Immune Homeostasis and Vascular Endothelial Function in Healthy Adults: A Randomized, Double-Blind, Parallel-Group Comparative Study.

Excessive immune response and inflammation are associated with an increased risk of various diseases. In particular, excessive myeloperoxidase (MPO) activity in neutrophils causes inflammatory reactions and lifestyle-related diseases. Adlay has a long history of being used as a traditional Chinese medicine.

Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice.

Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable models for exploring human hematology and immunology. However, sufficient recapitulation of human hematopoiesis in mice requires large quantities of enriched human CD34 HSCs and total-body irradiation for adequate engraftment. Recently, we generated a NOG mouse strain with a point mutation in the c-kit tyrosine kinase domain (W41 mutant; NOGW mice).

Ocular Signs and Testing Most Compatible with Sarcoidosis-Associated Uveitis: A Latent Class Analysis.

Purpose: This study aims to explore the potential subgroups of sarcoidosis-associated uveitis (SAU) within a multicenter cohort of uveitis participants.

Design: Cross-sectional study.

Participants: A cohort of 826 uveitis patients from a uveitis registry from 19 clinical centers in 12 countries between January 2011 and April 2015.

Theory of Collective Excitations in the Quadruple-Q Magnetic Hedgehog Lattices.

Hedgehog and antihedgehog spin textures in magnets behave as emergent monopoles and antimonopoles, which give rise to astonishing transport and electromagnetic phenomena. Using the Kondo-lattice model in three dimensions, we theoretically study collective spin-wave excitation modes of magnetic hedgehog lattices which have recently been discovered in itinerant magnets such as MnSi_{1-x}Ge_{x} and SrFeO_{3}. It is revealed that the spin-wave modes, which appear in the subterahertz regime, have dominant amplitudes localized at Dirac strings connecting hedgehog-antihedgehog pairs and are characterized by their translational oscillations.

Relationship between prehabilitation responsiveness and postoperative physical functional recovery in cardiovascular surgery.

Background: The purpose of this study was to examine the relationship between responsiveness to prehabilitation and postoperative recovery of physical function in cardiac surgery patients.

Methods: Ninety-three cardiac surgery patients (mean age: 76.4 years) were included in this retrospective cohort study.

Using the Natural Language Processing System Medical Named Entity Recognition-Japanese to Analyze Pharmaceutical Care Records: Natural Language Processing Analysis.

Background: Large language models have propelled recent advances in artificial intelligence technology, facilitating the extraction of medical information from unstructured data such as medical records. Although named entity recognition (NER) is used to extract data from physicians' records, it has yet to be widely applied to pharmaceutical care records.

Objective: In this study, we aimed to investigate the feasibility of automatic extraction of the information regarding patients' diseases and symptoms from pharmaceutical care records.