The Influence of Mesenchymal Stem Cell Wharton Jelly toward Gene Expression on Synoviocyte Cell Osteoarthritis.

Background: Pharmacological therapy in the management of OA causes many new health problems due to side effects caused by long-term use of drugs, such as long-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) will cause gastric ulcers and impaired kidney function. In OA pathogenesis, gene is involved in the inflammation process.

Aim: This study aims to identify the influence of Wharton Jelly Mesenchymal Stem Cell (MSC-WJ) on expression gene in synoviocyte by in vitro.

Anti-ulcerogenic effect and HPLC analysis of the caffeoylquinic acid-rich extract from Ligularia stenocephala.

The leaves of three Ligularia species belonging to the family Compositae, Ligularia stenocephala, L. fischeri, and L. fischeri var.