Publications by authors named "Mobina Tabibian"

Non-coding RNAs affect carcinogenic processes in diverse tissues, such as prostate. Several of these transcripts act as oncogenes driving prostate cancer. Thus, they are putative targets for treatment of this type of cancer.

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Background: Prostate cancer is among prevalent cancers in men. Numerous strategies have been proposed to intervene with the important prostate cancer-related signaling pathways. Among the most promising strategies is CRISPR/Cas9 strategy.

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The gram-negative bacterium Escherichia coli Nissle 1917 (EcN) has long been recognized for its therapeutic potential in treating various intestinal diseases. Bacterial ghosts (BGs) are empty shells of non-living bacterial cells that demonstrate enormous potential for medicinal applications. Genetic and chemical techniques can create these BGs.

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Article Synopsis
  • The study investigates the mRNA expression and DNA methylation of specific genes (TCF4, MBP, EGR1) in the blood of schizophrenia (SCZ) patients compared to healthy controls.
  • There were notable differences in gene expression: TCF4 showed a decrease, while MBP increased in SCZ patients.
  • The findings suggest that these gene expression changes correlate with the severity of symptoms and cognitive performance, which could lead to the development of diagnostic biomarkers for SCZ.
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Objective: Schizophrenia is an acute mental disorder with an undefined etiology. Its high heritability suggests that several genetic variants and polymorphisms may contribute to the severity and emergence of its symptoms. Former molecular evidence has shed some light on the association of serotonergic pathway genetic polymorphisms with schizophrenia.

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