The Safety and Effectiveness of Apixaban in Patients with End-Stage Kidney Disease on Dialysis: A Retrospective Observational Study.

Apixaban has been increasingly utilized for various FDA-approved indications, including stroke prevention and venous thromboembolism (VTE) treatment in patients with end stage kidney disease (ESKD) on hemodialysis. However, the safety and efficacy of its use in this population is not well established. Hence, the purpose of this study is to evaluate the safety and effectiveness of apixaban by examining outcomes in this population.

Aberrant expression of β-catenin in invasive ductal breast carcinomas.

Background And Purpose: β-catenin has crucial roles in cell-cell adhesion as well as Wingless (Wnt) signaling pathway, which is closely associated with carcinogenesis. The aim of this study was to evaluate the expression of β-catenin in invasive ductal breast carcinomas and investigate its associations with known clinicopathological parameters, estrogen receptor (ER), progesterone receptor (PR) and tumor proliferative activity then, to explore βcatenin expressional differences in primary tumors and corresponding axillary lymph node metastasis (ALNM).

Material And Methods: Immunohistochemistry using streptavidin biotin immunoperoxidase method was applied on 65 formalin-fixed paraffin-embedded primary invasive ductal breast carcinomas.