Publications by authors named "Moana Busch"
Low pH in the gut is associated with severe inflammation, fibrosis, and colorectal cancer (CRC) and is a hallmark of active inflammatory bowel disease (IBD). Subsequently, pH-sensing mechanisms are of interest for the understanding of IBD pathophysiology. Tissue hypoxia and acidosis-two contributing factors to disease pathophysiology-are linked to IBD, and understanding their interplay is highly relevant for the development of new therapeutic options.
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- * In experiments with mice lacking these receptors, it was found that the absence of OGR1 reduced inflammation and improved disease severity, while the lack of TDAG8 led to increased inflammation.
- * These findings suggest that targeting OGR1 and TDAG8 may offer new therapeutic strategies for treating IBD, as their interaction significantly impacts the intestinal inflammatory response.