Tumor Prognostic Risk Model Related to Monocytes/Macrophages in Hepatocellular Carcinoma Based on Machine Learning and Multi-Omics.

Tumor-associated macrophages (TAMs) are crucial in hepatocellular carcinoma (HCC) development and invasion. This study explores monocyte/ macrophage-associated gene expression profiles in HCC, constructs a prognostic model based on these genes, and examines its relationship with drug resistance and immune therapy responses. Single-cell RNA sequencing(scRNA-seq) data from 10 HCC tissue biopsy samples, totaling 24,597 cells, were obtained from the GEO database to identify monocyte/macrophage-associated genes.

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.

Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants remain inadequately understood. In this study, we report a genome-wide association study of HF and its subtypes in a sample of 1.

Oxygen Dopants in MoS Catalysts as Dual Anchors for a Lithium Polysulfide Chain to Accelerate Conversion to Solid LiS: A Strategy to Mitigate the Shuttle Effect in Li-S Batteries.

The development of lithium-sulfur batteries (LSBs) is hindered by the solubility of polysulfide intermediates. Herein, we synthesized oxygen-doped MoS on a highly conductive CNT as a cathode material for LSBs. The spaced oxygen dopants on the catalyst surface enable Li polysulfide chains to adsorb parallel to the catalyst surface.

EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research.

Shotgun metagenomics has become a pivotal technology in microbiome research, enabling in-depth analysis of microbial communities at both the high-resolution taxonomic and functional levels. This approach provides valuable insights of microbial diversity, interactions, and their roles in health and disease. However, the complexity of data processing and the need for reproducibility pose significant challenges to researchers.

Posttreatment FIB-4 score change predicts hepatocellular carcinoma in chronic hepatitis C patients: Findings from the Taiwan hepatitis C registry program.

Purpose: This study investigated whether Fibrosis-4 (FIB-4) score and its change can serve as predictors of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis C (CHC) infection receiving direct-acting antivirals (DAAs).

Methods: This study identified 9679 patients who completed DAA treatment and achieved sustained virologic response (SVR) from the Taiwan Nationwide Real-World HCV Registry Program, and their risk of HCC was analyzed.

Results: Multivariable Cox regression analyses identified diabetes mellitus (DM), alpha-fetoprotein (AFP) level, and FIB-4 score as independent predictors of HCC in both Model 1 (baseline) and Model 2 (SVR).

Effectively mitigated eutrophication risk by strong biological carbon pump (BCP) effect in karst reservoirs.

Karst reservoirs can significantly enhance the effect of biological carbon pump (BCP), a crucial process for carbon sequestration, water purification, and eutrophication mitigation. However, the effects of BCP on the fate of carbon (C), nitrogen (N), and phosphorus (P) and its role in regulating eutrophication within river-reservoir systems, remains insufficiently understood, particularly across different geological settings. We investigated the Hongfeng Reservoir (HFR), a typical karst reservoir, analyzing water chemistry, nutrient concentrations, and stable isotopes of dissolved inorganic carbon (δC) and nitrate (δN-NO) to uncover the underlying mechanisms governing the migration of biogenic elements and the process of eutrophication.

A Mo-doped carbon dot nanozyme for enhanced phototherapy .

Cancer is a leading cause of death globally, and traditional treatment methods often come with non-negligible toxic side effects in its treatment, threatening patients' quality of life. Thus, developing novel, efficient, low-toxicity cancer treatment strategies is crucial. Nanozymes, as a class of powerful nanomaterials, can subtly mimic the catalytic activity of natural enzymes, making them a formidable alternative.

Immune dysregulation in COVID-19 induced ARDS in kidney transplant recipients revealed by single-cell RNA sequencing.

Since the emergence of COVID-19 at the end of 2019, the disease has led to widespread acute respiratory distress syndrome (ARDS), particularly among kidney transplant recipients (KTRs), who are at increased risk due to long-term immunosuppressive therapy. This study aims to explore the differences in immune responses between kidney transplant recipients and non-kidney transplant recipients in COVID-19-induced ARDS to identify potential therapeutic targets for improving outcomes. Single-cell RNA sequencing was performed on 108,320 cells derived from peripheral blood samples to construct a global single-cell map of COVID-19 induced ARDS in kidney transplant recipients(ARDS), COVID-19 induced ARDS in non transplant recipients(ARDS), and healthy controls.

Comparison of drug-coated balloon with bare-metal stent in patients with symptomatic intracranial atherosclerotic stenosis: the AcoArt sICAS randomized clinical trial.

Background: Restenosis after stenting with a standard bare-metal stent (BMS) is the main cause of stroke recurrence for symptomatic intracranial atherosclerotic stenosis (sICAS). Whether a drug-coated balloon (DCB) could reduce the risk of restenosis for such patients is unknown. We aimed to investigate the efficacy and safety of DCB in reducing 6 month restenosis in patients with sICAS.

Adaptive Defense Mechanism During Flowering Period of Revealed by Comparative Transcriptomic Analysis.

, a widely distributed species in southwestern China, is recognized not only for its significant ornamental value but also as a culinary resource for local tribes. However, the defense mechanisms underlying the ecological adaptations of remain to be elucidated. In this study, we conducted comparative transcriptomic analyses of various organs (corolla, androecium/gynoecium and leaves) of collected from two distinct two regions.

The associations of brain-derived neurotrophic factor (BDNF) levels with psychopathology and lipid metabolism parameters in adolescents with major depressive disorder.

Brain-derived neurotrophic factor (BDNF) is crucial for the growth, differentiation and maintenance of neuronal systems, which is closely associated with major depressive disorder (MDD). The objective of this study was to investigate the BDNF levels and their associations with psychopathology and lipid metabolism parameters in adolescents with MDD. From January to December 2021, the study included 141 adolescents with MDD and 90 healthy controls (HCs).

[Evaluation of Clinical Practicability of Hybrid Automatic Treatment Planning for Nasopharyngeal Carcinoma].

Objective: Automatic planning is a commonly used alternative to manual planning. This study evaluated the clinical performance of automatic plans available in commercial treatment planning systems for nasopharyngeal carcinoma (NPC) treatment by comparing automatic planning with manual planning.

Methods: A total of 14 patients with nasopharyngeal carcinoma were enrolled in the study.

Enhanced recognition and counting of high-coverage Amorphophallus konjac by integrating UAV RGB imagery and deep learning.

Accurate counting of Amorphophallus konjac (Konjac) plants can offer valuable insights for agricultural management and yield prediction. While current studies have primarily focused on detecting and counting crop plants during the early stages of low coverage, there is limited investigation into the later stages of high coverage, which could impact the accuracy of forecasting yield. High canopy coverage and severe occlusion in later stages pose significant challenges for plant detection and counting.

Designing vaping prevention messages for youth: a scoping review protocol.

Introduction: Youth vaping has become a significant public health concern globally. Effective prevention messages are essential to reduce the prevalence of vaping among young people. However, evidence on the design of youth vaping prevention messages is limited.

Microglial plasticity governed by state-specific enhancer landscapes.

Single-cell transcriptomic studies have identified distinct microglial subpopulations with shared and divergent gene signatures across development, aging and disease. Whether these microglial subsets represent ontogenically separate lineages of cells, or they are manifestations of plastic changes of microglial states downstream of some converging signals is unknown. Furthermore, despite the well-established role of enhancer landscapes underlying the identity of microglia, to what extent histone modifications and DNA methylation regulate microglial state switches at enhancers have not been defined.

Effect of W Modification on MoS Surface Edge in the Ethanolysis of Lignin into Platform Chemicals.

A series of metal-doped MoS, including W-, V-, and Re-doped MoS, are prepared via a two-step hydrothermal method, which presents higher activity on the depolymerization of enzymatic hydrolysis lignin (EHL) in ethanol as compared to undoped MoS. At 320 °C for 6 h, the highest overall aromatic monomer yield of 231 mg/g EHL, including alkylphenols (A-Ps) as the main products with a yield of 126.5 mg/g EHL, is obtained over two-step hydrothermally prepared W-doped MoS with the W/Mo molar ratio of 0.

Multi-omics integration analysis of the amino-acid metabolism-related genes identifies putatively causal variants of ACCS associated with hepatitis B virus-related hepatocellular carcinoma survival.

Background: Amino acid metabolism (AAM) reprogramming plays a crucial role in hepatocellular carcinoma (HCC), but its genetic pathophysiology was not fully elucidated. Therefore, we employed a summary data-based Mendelian randomization (SMR) approach to identify putative causal effects of the AAM-related genes on hepatitis B virus (HBV)-HCC survival via integrating multi-omics data.

Methods: Multivariate Cox proportional hazards regression models were used to evaluate associations between genetic variants of AAM-related genes and overall survival (OS) of HBV-HCC patients (n = 866).

A biodegradable capacitive-coupling neurostimulator for wireless electroceutical treatment of inflammatory bowel diseases.

Electroceuticals based on peripheral nerve stimulation offer promising treatment for refractory inflammatory diseases such as inflammatory bowel diseases (IBDs). For pediatric IBD (PIBD) patients, wireless, biodegradable miniaturized bioelectronic devices are crucial to prevent neural damage and support neural development during and after therapy. Here we demonstrate a battery-free, miniaturized neurostimulator based on biodegradable materials and capacitive-coupling wireless power transfer.

A single fluorescent probe for dual-color imaging and polarity precise analysis in lipid droplets and endoplasmic reticulum.

Background: Elaborating the subcellular polarity is pivotal for pathophysiological research and early disease diagnosis. Despite its significance, achieving simultaneous two-color fluorescence imaging and quantitative analysis of polarity across multiple organelles remains challenging. This limitation primarily stems from the lack of single fluorescent (SF) probes capable of such precise and multifaceted functionality.

Alteration in Cortical Structure Mediating the Impact of Blood Oxygen-Carrying Capacity on Gross Motor Skills in Infants With Complex Congenital Heart Disease.

Congenital heart disease (CHD) is the most common congenital anomaly, leading to an increased risk of neurodevelopmental abnormalities in many children with CHD. Understanding the neurological mechanisms behind these neurodevelopmental disorders is crucial for implementing early interventions and treatments. In this study, we recruited 83 infants aged 12-26.

Research advances in plant genome size in relation to functional traits and environmental adaptation.

Plant genome size, the sum of the DNA content of a complete set of haplo groups within a given plant species, is an important aspect of biological characterization. There is abundant genome size diversity in eukaryotes. Plant genome size is closely associated with a range of functional traits from the nucleus to individual level, exerts a vital role in shaping plant functional traits, and helps plants present different response strategies to environmental variables.

Normobaric hyperoxia combined with endovascular treatment for acute ischaemic stroke in China (OPENS-2 trial): a multicentre, randomised, single-blind, sham-controlled trial.

Background: Endovascular treatment improves the recanalisation rate for patients with acute ischaemic stroke; however, even with endovascular treatment, approximately half of patients do not have a favourable functional outcome. We aimed to evaluate the effect of normobaric hyperoxia combined with endovascular treatment on functional outcomes up to 90 days after treatment in patients who had an acute ischaemic stroke with large-vessel occlusion.

Methods: In this multicentre, randomised, single-blind, sham-controlled trial, patients aged 18-80 years presenting within 6 h of acute ischaemic stroke attributed to large-vessel occlusion in anterior circulation, who were candidates for endovascular treatment, were recruited from 26 comprehensive stroke centres in China.

Synergistic Zn and MoS Tailored Co-N/C Environments Enabling Bifunctional ORR/OER Electrocatalysis for Advanced Li-O Batteries.

To better adapt lithium-oxygen batteries (LOBs) and overcome their sluggish oxygen reduction and evolution reactions (ORR/OER) kinetics, designing efficient bifunctional ORR/OER catalytic materials is essential. In this study, we successfully constructed a bifunctional ZnCo-N/C@MoS catalyst by tailoring the Co-N/C center with Zn incorporation and MoS encapsulation. Surprisingly, Zn atoms, which are typically considered to promote the Co atoms isolation, exhibit a promoting effect on the ORR performance of Co-N/C centers and enhance their stability under harsh conditions.

High-normal and abnormal alanine transaminase levels linked to increased risk of hepatoma following treatment for chronic hepatitis C.

Background/purpose: The risk of hepatocellular carcinoma (HCC) is increased in patients with chronic hepatitis C (CHC) and elevated alanine transaminase (ALT) levels. The association between HCC and ALT levels after interferon (IFN) or direct-acting antivirals (DAA) therapy is unclear.

Methods: Patients with CHC receiving antiviral therapy were included in two large-scale cohorts in Taiwan (T-COACH and TACR).

Observation of Λ_{c}^{+}→Λa_{0}(980)^{+} and Evidence for Σ(1380)^{+} in Λ_{c}^{+}→Λπ^{+}η.

Based on 6.1  fb^{-1} of e^{+}e^{-} annihilation data collected at center-of-mass energies from 4.600 to 4.