Publications by authors named "Mo-Dan Li"
Background: Augmented reality (AR) technology is used to reconstruct three-dimensional (3D) images of hepatic and biliary structures from computed tomography and magnetic resonance imaging data, and to superimpose the virtual images onto a view of the surgical field. In liver surgery, these superimposed virtual images help the surgeon to visualize intrahepatic structures and therefore, to operate precisely and to improve clinical outcomes.
Data Sources: The keywords "augmented reality", "liver", "laparoscopic" and "hepatectomy" were used for searching publications in the PubMed database.
Aim: To develop a prognostic model to predict survival of patients with colorectal cancer (CRC).
Methods: Survival data of 837 CRC patients undergoing surgery between 1996 and 2006 were collected and analyzed by univariate analysis and Cox proportional hazard regression model to reveal the prognostic factors for CRC. All data were recorded using a standard data form and analyzed using SPSS version 18.
The response evaluation criteria in solid tumors, which are based on tumor size alone, are the most frequently used and effective criteria by which to evaluate the tumor response to chemotherapy. However, the mechanism of tumor-targeted drugs is different from traditional cytotoxic drugs. Tumor-targeted drugs are designed to interfere with specific aberrant biological pathways involved in tumorigenesis.
View Article and Find Full Text PDFClinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients.
World J Gastroenterol
February 2011
Article Synopsis
- - The study focused on identifying mutations in the K-ras and BRAF genes in 118 Chinese colorectal cancer patients to see how these mutations relate to clinical features and patient outcomes.
- - Results showed that 34.7% of patients had K-ras mutations, primarily at codons 12 and 13, with a significant association found between K-ras mutations and female gender; however, other clinical factors and patient survival were not linked to these mutations.
- - Only two patients had BRAF mutations, indicating that such mutations are rare in this population, while K-ras mutations appear common but do not serve as independent prognostic indicators for CRC.
This study reports a case of an advanced pancreatic cancer patient with liver metastasis who was treated with a combination of chemotherapy, targeted drugs, and high-intensity focused ultrasound (HIFU). The abdominal pain was successfully relieved after the HIFU therapy. The patient had an 18-month survival with satisfactory quality of life.
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