Comparison of comprehensive quantitative EEG metrics between typically developing boys and girls in resting state eyes-open and eyes-closed conditions.

Introduction: A majority of published studies comparing quantitative EEG (qEEG) in typically developing (TD) children and children with neurodevelopmental or psychiatric disorders have used a control group (e.g., TD children) that combines boys and girls.

Validation of Visually Identified Muscle Potentials during Human Sleep Using High Frequency/Low Frequency Spectral Power Ratios.

Surface electromyography (EMG), typically recorded from muscle groups such as the mentalis (chin/mentum) and anterior tibialis (lower leg/crus), is often performed in human subjects undergoing overnight polysomnography. Such signals have great importance, not only in aiding in the definitions of normal sleep stages, but also in defining certain disease states with abnormal EMG activity during rapid eye movement (REM) sleep, e.g.

Four methods of brain pattern analyses of fMRI signals associated with wrist extension versus wrist flexion studied for potential use in future motor learning BCI.

Objective: In stroke survivors, a treatment-resistant problem is inability to volitionally differentiate upper limb wrist extension versus flexion. When one intends to extend the wrist, the opposite occurs, wrist flexion, rendering the limb non-functional. Conventional therapeutic approaches have had limited success in achieving functional recovery of patients with chronic and severe upper extremity impairments.

Biomarkers Based on Comprehensive Hierarchical EEG Coherence Analysis: Example Application to Social Competence in Autism (Preliminary Results).

Electroencephalography (EEG) coherence analysis, based on measurement of synchronous oscillations of neuronal clusters, has been used extensively to evaluate functional connectivity in brain networks. EEG coherence studies have used a variety of analysis variables (e.g.

Strong correlation of novel sleep electroencephalography coherence markers with diagnosis and severity of posttraumatic stress disorder.

Objective biomarkers of the presence and severity of posttraumatic stress disorder (PTSD) are elusive, yet badly needed. Electroencephalographic (EEG) coherence represents a promising approach to identifying and understanding brain biomarker activity in PTSD. Overnight polysomnography data containing EEG across sleep and wake states was collected in n = 76 Veterans with and without PTSD from a single site under IRB approval.

EEG slow waves in traumatic brain injury: Convergent findings in mouse and man.

Objective: Evidence from previous studies suggests that greater sleep pressure, in the form of EEG-based slow waves, accumulates in specific brain regions that are more active during prior waking experience. We sought to quantify the number and coherence of EEG slow waves in subjects with mild traumatic brain injury (mTBI).

Methods: We developed a method to automatically detect individual slow waves in each EEG channel, and validated this method using simulated EEG data.

EEG slow waves in traumatic brain injury: Convergent findings in mouse and man.

Objective: Evidence from previous studies suggests that greater sleep pressure, in the form of EEG-based slow waves, accumulates in specific brain regions that are more active during prior waking experience. We sought to quantify the number and coherence of EEG slow waves in subjects with mild traumatic brain injury (mTBI).

Methods: We developed a method to automatically detect individual slow waves in each EEG channel, and validated this method using simulated EEG data.

Concordance of Actigraphy With Polysomnography in Traumatic Brain Injury Neurorehabilitation Admissions.

Objective: To examine concordance of accelerometer-based actigraphy (ACG) with polysomnography (PSG) in the determination of sleep states in inpatients with traumatic brain injury (TBI), and examine the impact of injury severity and comorbid conditions (spasticity, apnea) on concordance.

Participants: This was a convenience sample of 50 participants with primarily severe TBI.

Design: This was a retrospective chart review of concurrent administration of PSG with ACG in nonconsecutive rehabilitation admissions with TBI.

An electroencephalographic recording platform for real-time seizure detection.

There are currently no clinical devices that can be worn by epilepsy patients who suffer from intractable seizures to warn them of seizure onset. Here we summarize state-of-the-art therapies and devices, and present a second-generation hardware platform in which seizure detection algorithms may be programmed into the device. Bi-polar electrographic data is presented for a prototype device and future implementations are discussed.

Prospective evaluation of the nature, course, and impact of acute sleep abnormality after traumatic brain injury.

Objective: To prospectively characterize the prevalence, course, and impact of acute sleep abnormality among traumatic brain injury (TBI) neurorehabilitation admissions.

Design: Prospective observational study.

Setting: Freestanding rehabilitation hospital.