Publications by authors named "Mo H Larsen"
Detection of cocaine 24 h after administration before nasotracheal intubation.
Acta Anaesthesiol Scand
October 2024
Article Synopsis
- Cocaine can be used as a nasal spray to relieve congestion before nasotracheal intubation, but there are legal risks if it is detected in patients during driving after surgery.
- A study evaluated benzoylecgonine levels in saliva and cocaine levels in blood to see if they exceeded legal limits 1 and 24 hours post-surgery.
- Results showed that 13% of patients had detectable benzoylecgonine in saliva and 3% had detectable cocaine in blood 24 hours after administration, highlighting the need for patients to be cautioned against driving for at least a day post-surgery.
Background: Nasotracheal intubation is associated with a risk of epistaxis. Several drugs, including cocaine and xylometazoline may be used as decongestants prior to nasotracheal intubation to prevent this. We hypothesized that xylometazoline would prevent epistaxis more effectively than cocaine, demonstrated by a lower proportion of patients with bleeding after nasotracheal intubation.
View Article and Find Full Text PDFBackground: Cardiac surgery is associated with a risk of complications, including post-operative cognitive dysfunction (POCD). In the randomized Perfusion Pressure Cerebral Infarcts (PPCI) trial, we allocated cardiac surgery patients to either a low-target mean arterial pressure (40-50 mm Hg) or a high-target pressure (70-80 mm Hg). The study found no difference in the volume of new ischemic cerebral lesions nor POCD, but 30-day mortality tended to be higher in the high-target group.
View Article and Find Full Text PDFBackground: Spinal immobilisation of blunt trauma victims with potential spinal cord injury is considered standard of care. The traditional management has, however, been increasingly questioned and concerns about harm have been raised. Few studies have described the perspective of the trauma patient regarding the spinal immobilisation.
View Article and Find Full Text PDFIntroduction: Hyperoxaemia is commonly observed in trauma patients but has been associated with pulmonary complications and mortality in some patient populations. The objectives of this study were to evaluate whether maintenance of normoxia is feasible using a restrictive oxygen strategy in the initial phase after trauma and to evaluate the incidence of 30-day mortality and/or major pulmonary complications.
Methods: Forty-one adult trauma patients admitted to our trauma centre were randomised to 24 hours of restrictive oxygen therapy (no supplemental oxygen if the arterial oxyhaemoglobin saturation (SpO ) was at least 94%, n = 21) or liberal oxygen therapy (intubated patients: FiO 1.