Publications by authors named "Mo Chi Yang"
Objective: Retinoblastoma (RB) is a prevalent type of eye cancer in youngsters. Prospero homeobox 1 (Prox1) is a homeobox transcriptional repressor and downstream target of the proneural gene that is relevant in lymphatic, hepatocyte, pancreatic, heart, lens, retinal, and cancer cells. The goal of this study was to investigate the role of Prox1 in RB cell proliferation and drug resistance, as well as to explore the underlying Notch1 mechanism.
View Article and Find Full Text PDFBackground: Diabetic retinopathy and chronic kidney disease are both major complications of diabetes mellitus. We explored the relationship between retinal vessel density (VD) and albuminuria in diabetic patients without conventionally defined diabetic retinopathy.
Methods: The cross-sectional community-based Kailuan Diabetic Retinopathy Study included patients with type 2 diabetes without diabetic retinopathy who participated in the community-based longitudinal Kailuan study and who had undergone ocular fundus photography, kidney function assessment, and optical coherence tomographic angiography (OCT-angiography) for the assessment the retinal perfusion density (PD) and retinal VD.
Prevalence and Risk Factors of Epiretinal Membranes in a Chinese Population: The Kailuan Eye Study.
Invest Ophthalmol Vis Sci
September 2020
Article Synopsis
- The study aimed to determine the prevalence of epiretinal membranes (ERMs) and identify risk factors in a Chinese population of 14,440 participants with a mean age of 54 years.
- Results showed that 7.6% of participants had ERMs, with a notable association between higher rates of ERMs and older age, increased body mass index, smoking, elevated glucose levels, and lower uric acid levels.
- The findings indicate that ERMs can significantly affect visual acuity, particularly in cases with premacular fibroses compared to those with less severe forms like cellophane macular reflexes.
Aim: To explore the influencing factors of diabetes type 2 patients with mild non-proliferative diabetic retinopathy (NPDR) in the Kailuan area of Tangshan, Hebei Province, China.
Methods: In this non-interventional, retrospective study, 683 patients with type 2 diabetes were included in the Kailuan Diabetic Retinopathy Study involving participants with diabetes in the community-based longitudinal Kailuan Study. Based on the undilated ultra-wide field (200°; UWF) images and partial dilated digital fundus images, the diabetic retinopathy (DR) of the surveyed population was graded.
Ocular Axial Length and Diabetic Retinopathy: The Kailuan Eye Study.
Invest Ophthalmol Vis Sci
August 2019
Purpose: To examine the role of ocular axial length as an ocular parameter for the prevalence and severity of diabetic retinopathy (DR).
Methods: The cross-sectional Kailuan Diabetic Retinopathy Study included patients with diabetes who participated in the community-based longitudinal Kailuan Study and who had undergone ocular fundus photography. The fundus photographs were graded using the Early Treatment of Diabetic Retinopathy Study criteria.