[The agreed experts' position of the Eurasian Association of Therapists on tactics of management of patients with comorbid pathology infected with SARS-Cov-2].

The agreement of experts of the Eurasian Association of Therapists (EAT) discusses pathogenesis and treatment of COVID-19. Modern data on the characteristics of cardiovascular, kidney, respiratory damage in SARS-infected CoV-2 are presented. The tactics of managing patients initially having cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, bronchial asthma, chronic kidney disease are discussed in detail.

[Efficacy of metformin in abdominal obesity].

Aim: To study the effect of metformin on metabolic parameters, body weight (BW), and waist circumference (WC) in patients with abdominal obesity (AO).

Subjects And Methods: The results of using metformin 2000 mg daily for 3 months in 46 patients with AO. The comparison group consisted of 50 people.

[Cytokines and their role in pathogenesis of diabetic retinopathy].

The role of cytokines is estimated in development of diabetic retinopathy. Titer of cytokines is compared in healthy subjects and patients with impaired glucose metabolism. Fundus examination and specific cytokines level assessment allowed us to conclude that cytokines directly take part in pathogenesis of retinopathy before clinical manifestation.

[Mineral bone density and mineral exchange status in patients with chronic generalized periodontitis].

Chronic generalized periodontitis (CGP) development and course are closely related with somatic pathology. Systemic factors (Ca-regulating hormones level including) influence jaw bone tissue metabolism by resorptive processes reinforcing. We determined the degree of skeletal bone tissue mineralization and the level of Ca-regulating hormones in women with CGP of reproductive age and in postmenopausal period.

[Characteristics of immune system in patients with metabolic syndrome].

Aim: To characterize features of immune status in patients with metabolic syndrome (MS).

Material And Methods: 41 MS patients entered the study (mean age 55.9 +/- 9.

[Trends of physical fitness, physical performance, and blood circulation in children in response to graded exercises at a health center].

The article presents physiological features of the effect of summer conditioning of children on their physical performance and on circulation action of graded exercise. Physiological mechanisms of the influence which a complex of health factors have on body response to short-term physical exercise are described.

[Effect of reflex-segmental massage on central hemodynamics in healthy people].

Bioimpedance tetrapolar rheopolygraphy was made in 18-22-year-old athletes in lying position and active orthostasis using computer technology Kentavr PRS (Microlux). The study group of 40 men received a 10-day course of massage including classic massage of the spine and neck, reflex-segmental massage of the left scapula, region between the left scapula and the vertebral column, left great chest muscle and sites of left attachment of the ribs to the chest. The examinations were made before the massage and after it.

[The use of highly purified Iletin-II-type porcine insulins and human insulin preparations in clinical practice].

The paper presents the results of treatment with insulins of iletin-II and humulin series. Decreased insulin doses, absence of complications, stable compensation of diabetes mellitus, reduction of insulin antibodies titer suggest high clinical effectiveness of the above preparations. Because of low immunogenicity humulin insulins are preferable when compared to iletin-II ones.

[Osteocalcin in diffuse toxic goiter].

Bone metabolism was investigated in toxic goiter. The authors obtained evidence on high levels of osteocalcin which marks bone formation. The time of the thyroid function recovery during thyrostatic therapy and indices of phosphorus-calcium metabolism disagree indicating delayed normalization of the bone tissue metabolism.

[Status of phosphorus-calcium metabolism and secretion of calcium- regulating hormones in diabetic nephropathy].

The studies performed by the authors led them to the conclusion that diabetic nephropathy aggravates derangement of phosphoric--calcium metabolism in patients with diabetes mellitus. Secondary hyperparathyroidism, as a result of negative calcium balance in decompensated diabetes mellitus and renal dysfunction, contributes to development of marked alterations of the osteoarticular system.