Publications by authors named "Mizuta T"

The relationship between nanoliposomal irinotecan/fluorouracil/leucovorin (NFF) treatment outcomes and neutropenia in patients with pancreatic cancer has not been thoroughly examined. Thus, we conducted a retrospective analysis of data from patients with pancreatic cancer who were treated with NFF to investigate this relationship. Neutropenia was assessed according to the Common Terminology Criteria for Adverse Events across three cutoffs: A (grade 0 versus grade 1-4), B (grades 0-1 versus 2-4), and C (grades 0-2 versus 3-4).

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Introduction: Fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) improve overall survival (OS) and progression-free survival (PFS) in patients with pancreatic cancer, compared with gemcitabine (GEM). However, whether PFS is a surrogate marker of OS in pancreatic cancer chemotherapy focusing on FOLFIRINOX or GEM plus nab-paclitaxel remains unknown. We aimed to verify whether PFS can be a surrogate marker of OS in prognosis prediction.

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Background: Brain-dedicated positron emission tomography (PET) systems offer high spatial resolution and sensitivity for accurate clinical assessments. Attenuation correction (AC) is important in PET imaging, particularly in brain studies. This study assessed the reproducibility of attenuation maps (µ-maps) generated by a specialized time-of-flight (TOF) brain-dedicated PET system for imaging using different PET tracers.

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Article Synopsis
  • - This study compared the effectiveness of second-line treatments for patients with unresectable pancreatic cancer who previously received gemcitabine plus nab-paclitaxel (GnP), analyzing 318 patients treated with nanoliposomal irinotecan plus 5-fluorouracil/folinic acid (NFF), S-1, or FOLFIRINOX.
  • - Results showed that the median overall survival (OS) for the NFF group was significantly better at 9.08 months compared to 4.90 months for S-1, while FOLFIRINOX had an OS of 4.77 months with no significant difference from NFF.
  • - Factors like serum levels and duration
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Nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard regimen after gemcitabine-based therapy for patients with unresectable or recurrent pancreatic cancer. However, there are limited clinical data on its efficacy and safety in the real-world. We therefore initiated a retrospective and prospective observational study (NAPOLEON-2).

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Deep learning (DL) has recently attracted attention for data processing in positron emission tomography (PET). Attenuation correction (AC) without computed tomography (CT) data is one of the interests. Here, we present, to our knowledge, the first attempt to generate an attenuation map of the human head via Sim2Real DL-based tissue composition estimation from model training using only the simulated PET dataset.

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First-line chemotherapy for patients with metastatic pancreatic cancer (MPC) includes gemcitabine plus nab-paclitaxel (GnP) and FOLFIRINOX (FFX). However, the efficacy of second-line chemotherapy and the role of combination chemotherapy in clinical practice is still unknown. Data was gathered from 14 hospitals in the Kyushu area of Japan from December 2013 to March 2017.

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Adolescent and young adult (AYA) patients with cancer have few opportunities to connect with patients of the same generation while hospitalized. Although anxiety is frequently reported by them, there are no reports on the psychological effectiveness of an in-hospital patient support program based on peer support. This study aimed to evaluate the effectiveness of a program, termed Adolescent and Young Adult Hiroba (AYA Hiroba), for anxiety in AYA patients with cancer.

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  • This study explores ways to create high-valent iridium complexes, which are typically made using specific types of ligands.
  • The research focuses on a unique anionic bis(CCC-pincer) Ir complex that can undergo a stepwise oxidation process, leading to the formation of distinct cationic and tricationic complexes.
  • These findings highlight the ability of organic π ligands to enhance the electronic properties of iridium complexes, thus overcoming previous synthetic challenges.
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  • Limited biomarkers exist for predicting prognosis in unresectable pancreatic cancer patients undergoing chemotherapy.
  • A study of 255 patients found that lower C-reactive protein/albumin ratio (CAR) and several other inflammatory markers were linked to better overall survival (OS) in first-line treatment.
  • CAR was identified as the most effective prognostic indicator, suggesting it could serve as a valuable biomarker for assessing patient outcomes in both first- and second-line chemotherapy.
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Although adolescent and young adult (AYA) cancer patients are digital natives and have high digital communication needs, previous studies of screening tools for AYAs have primarily used paper when measuring patient-reported outcomes (PROs). There are no reports on using an electronic PRO (ePRO) screening tool with AYAs. This study evaluated the feasibility of such a tool in clinical settings, and assessed the prevalence of AYAs' distress and supportive care needs.

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  • Patients with metastatic pancreatic cancer who do not respond to first-line chemotherapy have limited treatment options, and it's uncertain which patients benefit from second-line chemotherapy.
  • A study involving 233 patients analyzed the effectiveness of second-line chemotherapy compared to best supportive care, using a scoring system based on specific prognostic factors like serum albumin and CA19-9 levels.
  • Results showed that patients with scores of 0 and 1 had a significant survival benefit from second-line chemotherapy, while those with score 2 did not experience similar advantages.
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Purpose: The actual state of mental health care use and related factors in adolescent and young adult (AYA) patients with cancer is not well understood in Japan. This study aimed to (1) examine the actual state of mental health care use among AYA patients with cancer and (2) describe socio-demographic and related factors associated with mental health care use.

Methods: We retrospectively reviewed the medical records of AYA patients with cancer aged 15-39 who first visited the National Cancer Center Hospital in Japan (NCCH) between January 2018 and December 2020.

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  • Recent advances in chemotherapy for unresectable pancreatic cancer (uPC) offer the possibility of conversion surgery (CS), but its effectiveness with specific treatments like FOLFIRINOX (FFX) and gemcitabine plus nab-paclitaxel (GnP) is still being evaluated.
  • A study reviewed 318 uPC patients treated with FFX or GnP and found that CS was achieved in only 4.3% of cases, with a higher success in locally advanced pancreatic cancer (LAPC) compared to metastatic cases (MPC).
  • Factors linked to a higher chance of CS include having LAPC, absence of liver metastasis, lower CA19-9 levels, and a good response to chemotherapy; overall
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Background: This study evaluated the physical performance of a positron emission tomography (PET) system dedicated to the head and breast according to the National Electrical Manufacturers Association (NEMA) NU2-2012 standard.

Methods: The spatial resolution, sensitivity, scatter fraction, count rate characteristics, corrections for count losses and randoms, and image quality of the system were determined. All measurements were performed according to the NEMA NU2-2012 acquisition protocols, but image quality was assessed using a brain-sized phantom.

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  • The study compares the efficacy and toxicity of the original FOLFIRINOX (oFFX) and a modified version (mFFX) for treating metastatic pancreatic cancer (mPC) in a Japanese patient population.
  • A multicenter analysis of 318 patients revealed no significant difference in overall survival and progression-free survival between oFFX and mFFX, although oFFX had higher rates of thromobocytopenia and liver dysfunction.
  • The findings suggest that mFFX is as effective as oFFX while causing fewer side effects, making it a safer option in clinical practice.
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Objectives: This study evaluates the phantom attenuation correction (PAC) method as an alternative to maximum-likelihood attenuation correction factor (ML-ACF) correction in time-of-flight (TOF) brain positron emission tomography (PET) studies.

Methods: In the PAC algorithm, a template emission image [Formula: see text] and a template attenuation coefficient image [Formula: see text] are prepared as a data set based on phantom geometry. Position-aligned attenuation coefficient image [Formula: see text] is derived by aligning [Formula: see text] using parameters that match the template emission image [Formula: see text] to measured emission image [Formula: see text].

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We acquired brain F-FDG and F-flutemetamol PET images using a time-of-flight system dedicated to the head (dhPET) and a conventional whole-body PET/CT (wbPET) system and evaluated the clinical superiority of dhPET over wbPET. There were 18 subjects for the F-FDG PET study and 17 subjects for the F-flutemetamol PET study. F-FDG PET images were first obtained using wbPET, followed by dhPET.

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Copper(I) oxide nanocubes were wrapped with an extremely uniform organic layer grown by self-controlled, Cu-mediated catalysis. This layer aided in retaining the initial cubic structure of the copper nanocubes during their use as a CO reduction electrocatalyst, resulting in high CO reduction selectivity by strong suppression of hydrogen evolution because of exclusion of water from the surface.

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Background: Pulmonary hypertension (PH) is an important cause of morbidity and mortality, which leads to a substantial loss of exercise capacity. PH ultimately leads to right ventricular overload and subsequent heart failure and early death. Although early detection and treatment of PH are recommended, due to the limited responsiveness to therapy at late disease stages, many patients are diagnosed at a later stage of the disease because symptoms and signs of PH are nonspecific at earlier stages.

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