Publications by authors named "Mizusa Hyodo"
Aims/introduction: This study examined the effects of high-intensity interval walking training (IWT) compared to moderate-intensity continuous walking training (CWT) on muscle strength, walking ability, and health-related quality of life (QOL) in people with diabetes accompanied by lower extremity weakness.
Materials And Methods: People with diabetes accompanied by low isometric knee extensor strength using a simple manual dynamometer (n = 50) were screened and randomly divided into 2 groups: CWT (n = 25) and IWT (n = 25). Both groups were instructed by a physical therapist to perform walking training with the goal of 120 min/week over a 5-month period.
Skeletal muscle atrophy impairs quality of life and increases the risk of disease, but current methods for assessment of muscle mass have several limitations. We here investigated the urinary concentration of a fragment of the muscle protein titin as a potential biomarker for the early detection of skeletal muscle atrophy. Four mouse models with different atrophy pathways were studied: those of cardiotoxin-induced acute muscle injury, cast-induced muscle immobilization, lipopolysaccharide-induced sepsis, and streptozotocin-induced diabetes.
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- Fluoroquinolones, common antibiotics, have been linked to aortic disease, leading to an FDA warning, but recent studies challenge this risk perception.
- The study focused on levofloxacin's impact on aortic dissection through both lab tests and mouse models, revealing endothelial cell damage in vitro but no significant increase in aortic dissection risk in vivo.
- Overall, despite some harmful effects observed in lab settings, the research concludes that fluoroquinolones do not significantly increase the risk of aortic dissection in clinical practice, suggesting their continued use is safe while recommending further studies for clarity.
Objective: Dysgeusia is a serious problem in patients with diabetes because it often leads to overeating, which is associated with disease progression. This study aimed to investigate the association between taste sensitivity, eating habits, and the oral environment.
Subjects And Methods: In this cross-sectional study of 75 subjects with diabetes, gustatory function was assessed using the whole-mouth method, and lingual taste receptor gene expression was measured by real-time PCR.