Publications by authors named "Mizuki Sugimoto"
Chem Pharm Bull (Tokyo)
September 2024
Article Synopsis
- Twisted intramolecular charge transfer (TICT) occurs when certain fluorescent dyes, upon being excited by light, undergo charge transfer and rotation that typically leads to non-fluorescence.
- Researchers found that modifying the size of substituents on rhodamine derivatives can adjust the strength of TICT and the resulting intramolecular steric repulsion.
- They developed a fluorescence probe that leverages this concept to detect nitroreductase (NTR) activity, which initially shows little fluorescence but dramatically increases when the NTR enzyme reacts with the probe, confirming that the intended chemical reactions occur.
