Publications by authors named "Mizuki Hiroki"
Article Synopsis
- - A novel indole alkaloid named vincazalidine A was discovered from the plant Catharanthus roseus, featuring a unique structure that combines elements of aspidosperma and iboga types with a complex ring system.
- - The chemical structure and stereochemistry of vincazalidine A were determined using various spectroscopic techniques and statistical analysis.
- - Vincazalidine A was found to cause G2 phase cell cycle arrest and trigger apoptosis in A549 human lung cancer cells, suggesting its potential as an anti-cancer agent.
A dimeric indole alkaloid, isovincathicine consisting of an aspidosperma type and modified iboga with C-7-C-20 connection type skeletons was first isolated from Catharanthus roseus, and the structure including stereochemistry was elucidated on the basis of spectroscopic data as well as DP4 statistical analysis. Isovincathicine inhibited cell proliferation in A549 cells. We investigated the detailed mode of action of isovincathicine-induced inhibitory effects on cell proliferation in A549 cells.
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