Publications by authors named "Miyuki Yamamoto"

Article Synopsis
  • - The study investigates how platelet function, measured through thromboelastography (TEG), relates to the severity of disseminated intravascular coagulation (DIC) in patients suffering from heatstroke at an emergency department. - Researchers analyzed data from 31 heatstroke patients in the ICU, finding a strong correlation between platelet function and DIC severity, indicating that impaired platelet function is linked to worse DIC outcomes. - The findings suggest that evaluating platelet function with TEG can improve our understanding of heatstroke complications, particularly in identifying different subtypes of the condition.
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Introduction: Tachycardia caused by sympathetic overactivity impairs myocardial function and raises septic patients' mortality. This study examined whether tachycardia is associated with acute kidney injury (AKI) period-prevalence among critically ill patients with and without sepsis.

Methods: In 328 patients (119 sepsis and 209 non-sepsis) admitted to our intensive care unit (ICU), we assessed heart rate at ICU admission, plasma neutrophil gelatinase-associated lipocalin (NGAL) and N-terminal pro-B-type natriuretic peptide, and urinary L-type fatty acid-binding protein and N-acetyl-β-d-glucosaminidase (NAG) at 0 and 48 h after admission.

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Background: The clinical value of the trajectory of temporal changes in acute kidney injury (AKI) biomarkers has not been well established among intensive care unit (ICU) patients.

Methods: This is a single-center, prospective observational study, performed at a mixed ICU in a teaching medical institute in Tokyo, Japan. Adult ICU patients with an arterial line and urethral catheter were enrolled from September 2014 to March 2015.

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Aim: Early diagnosis of acute pancreatitis is crucial, and urinary trypsinogen has been recently reported as a useful biomarker for diagnosing acute pancreatitis. We aimed to evaluate the impact of renal dysfunction on the diagnostic performance of urinary trypsinogen-2 for acute pancreatitis.

Methods: We conducted a retrospective study using the clinical data of patients who visited the Department of Emergency and Critical Care at the University of Tokyo Hospital between 1 October, 2021, and 30 June, 2022.

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Since the establishment of Japan's publicly supported pediatric home medical care (PHMC) system in 2012, the number of technology-dependent children (TDC) who are supported by PHMC has been increasing. We expected care to become easier as TDC mobility increased. However, many family caregivers complained of the opposite, that the burden of care increased as TDC's mobility increased.

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The majority of bite wounds that we encounter in the emergency department are caused by dogs, cats and humans, but bite injuries can be caused by a variety of animals. Here, we describe a case of bite wound and trauma caused by a large gorilla (Western lowland gorilla) weighing over 170 kg. Gorilla bites are rare, and the patient had an open fracture of the right distal radioulna in addition to multiple bite wounds.

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Article Synopsis
  • Patients with acute bronchospasm may show a specific capnogram pattern known as the "shark fin," which indicates uneven alveolar exhalation.
  • This study focuses on a 53-year-old male asthma patient who was intubated for a severe asthma attack and underwent monitoring of the capnogram slope during his 10-day ventilation.
  • The findings indicate that the phase III slope of the capnogram can decrease earlier than the end-tidal carbon dioxide (EtCO) levels, suggesting that capnogram waveforms could effectively track treatment responses in intubated patients experiencing acute bronchospasm.
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Background: Several clinical guidelines recommend monitoring blood lactate levels and central venous oxygen saturation for hemodynamic management of patients with sepsis. We hypothesized that carbon dioxide production (VCO) and oxygen extraction (VO) evaluated using indirect calorimetry (IC) might provide additional information to understand the dynamic metabolic changes in sepsis.

Methods: Adult patients with sepsis who required mechanical ventilation in the intensive care unit (ICU) of our hospital between September 2019 and March 2020 were prospectively enrolled.

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Introduction: Transient receptor potential vanilloid 4 (TRPV4) modulates osteoarthritic (OA) pain in animal models. However, the pathophysiological function of TRPV4 in regulating OA pain remains poorly understood.

Methods: We developed TRPV4-knockout (TRPV4-KO) rats and assessed the effects of gene deficiency in a monoiodoacetate (MIA)-induced OA pain model (MIA rats) by examining pain-related behavior, pathological changes, and electrophysiological changes in dorsal root ganglion (DRG) neurons.

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  • A study investigated the frequencies of bystander-initiated CPR and defibrillator use during out-of-hospital cardiac arrests (OHCA) in Tokyo from 2013 to 2017, categorizing actions as autonomous, non-autonomous, or undetermined.
  • The research revealed that locations classified as autonomous (especially outside the home) had low rates of CPR (38.6%) and AED usage (15.1%) compared to non-autonomous settings (68.3% and 26.8%, respectively).
  • The findings indicate that citizens often do not take autonomous action in emergencies, highlighting the need for improved education and training in CPR to increase bystander intervention rates.
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A treatment option for constipation that improves the quality of life is needed since available laxatives do not effectively improve the quality of life in patients with constipation. A significant association between gut dysbiosis and constipation is recognized, suggesting that probiotics may be an important option for management of constipation. The underlying mechanism by which probiotics improve constipation remains unclear.

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Transient receptor potential vanilloid 4 (TRPV4) is a non-selective cation channel activated by various physical stimuli such as cell swelling and shear stress. TRPV4 is expressed in bladder sensory nerves and epithelium, and its activation produces urinary dysfunction in rodents. However, there have been few reports regarding its involvement in bladder pain.

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Wells syndrome or eosinophilic cellulitis is an idiopathic inflammatory dermatitis characterized by a benign but recurrent evolution. It often causes edematous urticarial plaques on the extremities. Herein, we report two rare cases of Wells syndrome with marked swelling in the hands.

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Background: Capillary refill time (CRT) is a non-invasive technique to evaluate tissue perfusion, and quantitative CRT (Q-CRT) adapted to pulse oximetry was developed with patients with sepsis and compared to blood lactate and sepsis scores. In post liver transplantation, large amounts of fluid administration are necessary for maintaining tissue perfusion to grafted liver against intravascular hypovolemia. This study aimed to evaluate whether Q-CRT can predict poor outcomes by detecting peripheral tissue perfusion abnormality in patients with liver transplantations who were treated with massive fluid administration.

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