Publications by authors named "Miyuki Takasu"
Introduction: High-dose chemotherapy followed by autologous stem cell transplant is the mainstay of treatment for multiple myeloma (MM). The purpose of this study was to evaluate the ability of MRI-derived indices to predict mobilized hematopoietic stem cell yield.
Materials And Methods: In this exploratory pilot work, we retrospectively analyzed 38 mobilization procedures for MM.
Central nervous system methotrexate-associated lymphoproliferative disorder (CNS-MTX-LPD) is rare, but its spontaneous regression has been observed in some patients after withdrawal of agents. We herein report three cases of primary CNS-MTX-LPD that received oral MTX for rheumatoid arthritis. Epstein-Barr virus and oligoclonal bands (OCBs) were positive, while proton magnetic resonance spectroscopy (H-MRS) showed an elevated lipid peak and slightly elevated choline/N-acetylaspartate ratio in common.
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- A study was conducted to assess the effectiveness of chemical shift imaging (CSI) in distinguishing myelomatous infiltration from healthy bone marrow in patients with myeloma and control subjects.
- The researchers analyzed MRI data from 76 myeloma patients and 30 control participants, measuring fat-signal fraction (FF) and signal dropout ratio (DR) to evaluate disease severity.
- It was found that CSI did not effectively differentiate between the two types of bone marrow, but in patients with high cellularity, a small signal drop indicated a higher tumor burden, while low cellularity did not correlate with disease severity.
Article Synopsis
- The study aimed to evaluate how changes in total diffusion volume from whole-body diffusion-weighted imaging (WB-DWI) and fat fraction of lumbar bone marrow (BM) could predict remission status in multiple myeloma patients after chemotherapy.
- Fifty patients with symptomatic myeloma were assessed before and after two cycles of chemotherapy, and their results were classified into two categories based on their remission status.
- The findings indicated that early changes in fat fraction and serum M protein significantly predicted better remission outcomes (CR/very good PR), highlighting the value of MRI in early treatment assessment.
Purpose: The aim of this study was to compare the tumor conspicuity on actual measured diffusion-weighted images (aDWIs) and computed DWI (cDWI) of human breast tumors and to examine, by use of a phantom, whether cDWI improves their conspicuity.
Materials And Methods: We acquired DWIs (b-value 0, 700, 1400, 2100, 2800, and 3500 s/mm) of 148 women with breast tumors. cDWIs with b-values of 1400, 2100, 2800, and 3500 s/mm were calculated from aDWI scans where b = 0 and 700 s/mm; the tumor signal-to-noise ratio (SNR) was compared at each b-value.
The number of computed tomography(CT)-guided interventional procedures has increased because they are less invasive and more cost-effective than open surgery. Transarterial chemoembolization(TACE)is a method in which chemotherapeutic drugs are injected into the artery that supplies the tumor. It is also well known that multidetector-CT has tremendously advanced our diagnostic capabilities broadly throughout medicine.
View Article and Find Full Text PDFIntroduction: To evaluate the effectiveness of iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) magnetic resonance imaging (MRI) to discriminate between symptomatic and asymptomatic myeloma in lumbar bone marrow without visible focal lesions.
Materials And Methods: The lumbar spine was examined with 3-T MRI in 11 patients with asymptomatic myeloma and 24 patients with symptomatic myeloma. The fat-signal fraction was calculated from the ratio of the signal intensity in the fat image divided by the signal intensity of the corresponding ROI in the in-phase IDEAL image.
Article Synopsis
- The study investigates the long-term effects of computed tomography (CT) on bone health, specifically looking at osteoporosis in patients who have undergone transarterial chemoembolization (TACE) for liver cancer.
- Researchers compared bone density and microstructure in TACE patients to those with chronic hepatitis and healthy controls, finding a significantly higher prevalence of osteoporosis in the TACE group.
- Cumulative radiation exposure from routine dynamic CT scans emerged as a notable risk factor for developing osteoporosis, particularly influenced by patient sex and age.
Article Synopsis
- This study focused on how lenalidomide and bortezomib affect bone health in patients with multiple myeloma, specifically looking at bone microarchitecture and biomechanics through CT scans and finite element modeling (FEM).
- Thirty-two patients received bortezomib and 18 received lenalidomide, with results indicating that bortezomib led to decreased bone strength measurements, while lenalidomide significantly improved measures of bone strength such as failure load and stiffness.
- The research found that patients who responded well to lenalidomide treatment experienced notable gains in bone strength, showcasing the potential benefits of this drug on bone health compared to bortezomib.
Purpose: To compare various pulse sequences in terms of percent contrast and contrast-to-noise ratio (CNR) for detection of focal multiple myeloma lesions and to assess the dependence of lesion conspicuity on the bone marrow plasma cell percent (BMPC%).
Materials And Methods: Sagittal T1-weighted FSE, fat-suppressed T2-weighted FSE (FS- T2 FSE), fast STIR and iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) imaging of the lumbar spine were performed (n = 45). Bone marrow (BM)-focal myeloma lesion percent contrast and CNR were calculated.
Introduction: Our aim was to systematically investigate radiographic characteristics and outcome of diffusion-weighted imaging (DWI) changes in the elective coiling of unruptured cerebral aneurysm with analyzing the correlation of antiplatelet therapy (APT).
Methods: In a total of 34 consecutive patients with unruptured cerebral aneurysms initially treated by coiling without stent assist, 26 (76.5%) had DWI changes with 91 high signal spots within 24-48 h after the procedure.
Objectives: To evaluate the effectiveness of the iterative decomposition of water and fat with echo asymmetric and least-squares estimation (IDEAL) MRI to quantify tumour infiltration into the lumbar vertebrae in myeloma patients without visible focal lesions.
Methods: The lumbar spine was examined with 3 T MRI in 24 patients with multiple myeloma and in 26 controls. The fat-signal fraction was calculated as the mean value from three vertebral bodies.
Introduction: We investigated the correlation between age and the fractional anisotropy (FA) values of peripheral nerves in healthy adults and compared the age-corrected FA values of peripheral nerves in healthy subjects and patients with polyneuropathy.
Methods: The institutional review board approved this study and informed consent was obtained from all participants before entry into the study. We optimized diffusion tensor imaging using a 3-T magnetic resonance scanner and an extremity coil for scanning tibial nerves.
Purpose: The aim of this study was to compare the three-dimensional fat-suppressed balanced non-steady-state free precession (3D FS-nSSFP) sequence and the 3D T1-weighted spoiled gradient-recalled echo (3D T1-GRE) sequence for evaluating lumbar nerve root compression with continuous thin-slice coronal magnetic resonance (MR) images.
Materials And Methods: The institutional review board approved this study, and written informed consent was obtained from all 35 patients. We optimized continuous 2.
Purpose: To evaluate the accuracy of trabecular analysis of the lumbar spine by using multidetector computed tomography (CT) in differentiating multiple myeloma patients without spinal fractures from control subjects.
Materials And Methods: This retrospective single-institution study was approved by the institutional review board, with a waiver of informed consent. Spinal microarchitecture was examined by using 64-detector row CT in 29 patients with multiple myeloma and 51 control subjects.
Introduction: The purpose of this study was to assess the clinical feasibility of diffusion tensor imaging (DTI) for the evaluation of peripheral nerves in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
Methods: Using a 3-T magnetic resonance imaging scanner, we obtained DTI scans of the tibial nerves of 10 CIDP patients and 10 sex- and age-matched healthy volunteers. We prepared fractional anisotropy (FA) maps, measured the FA values of tibial nerves, and compared these values in the two study groups.
We report a case of MELAS in which lesions were detected by perfusion-weighted MR imaging. Perfusion-weighted MRI using contrast media (PWI) and FAIR (flow-sensitive alternating inversion recovery), an arterial spin labeling method, clearly showed these lesions as hyperperfused areas. One of these lesions, diminished after steroid therapy, could also be detected by FAIR.
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