Publications by authors named "Miyuan Zhang"
Article Synopsis
- Recent research into mushroom-derived compounds like psilocybin and psilocin emphasizes their psychedelic effects and potential use in treating mental health issues, such as depression.
- *The study investigates how the placement of the hydroxyl group on the indole ring influences the compounds' activity at 5-HT receptors and their psychedelic-like effects, finding that compounds with hydroxyl groups in the 4th and 5th positions are more effective.
- *Simulations reveal that specific hydrogen bonds and interactions with receptor residues are critical for the compounds' effectiveness, indicating that small structural changes can significantly impact their therapeutic potential.*
Psychedelics and Consciousness: Expanding the Horizons of Mind and Therapy.
Research (Wash D C)
October 2024
Psychedelics have long been recognized not only for their profound impact on human consciousness but also for their potential therapeutic applications. This perspective explores the multifaceted relationship between psychedelics and consciousness, emphasizing their capacity to alter sensory perceptions, disrupt self-referential thought processes, and catalyze profound spiritual and existential experiences. As research advances, psychedelics are being integrated into therapeutic settings, challenging existing psychiatric models and offering new insights into the complex nature of consciousness and mental health.
View Article and Find Full Text PDFBiased pharmacological modulators provide potential therapeutic benefits, including greater pharmacodynamic specificity, increased efficiency and reduced adverse effects. Therefore, the identification of such modulators as drug candidates is highly desirable. Currently, attention was mainly paid to biased signaling modulators targeting G protein-coupled receptors (GPCRs).
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