Publications by authors named "Miyu Sonoda"
Extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is a rare subtype of non-Hodgkin lymphoma (NHL) with poor prognosis, particularly in relapsed or refractory patients. Thus, timely detection of relapse and appropriate disease management are crucial. We present two patients with ENKTL, wherein positron emission tomography-computed tomography (PET-CT) with total-body coverage after induction therapy, detected newly relapsed regions in the bone marrow of the lower leg prior to progression.
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- Cancer cells often increase glycolysis, leading to high lactate production, which can be toxic; HTLV-1 bZIP factor (HBZ) enhances the release of lactate in adult T-cell leukemia-lymphoma (ATL) by upregulating the protein TAp73.
- HBZ reduces the binding of a repressor protein (EZH2) to the TAp73 promoter, while simultaneously promoting TAp73 transcription through specific molecular pathways, ultimately increasing the lactate transporters MCT1 and MCT4.
- Inhibiting TAp73 causes lactate buildup, resulting in cell death, and targeting MCT1/4 can reduce ATL cell growth, linking TAp73 and lactate transporters to cancer