Publications by authors named "Miyoko Maeda"
The aim of this study is to elucidate the detailed mechanism of endoplasmic reticulum (ER) stress-induced auditory cell death based on the function of the initiator caspases and molecular complex of necroptosis. Here, we demonstrated that ER stress initiates not only caspase-9-dependent intrinsic apoptosis along with caspase-3, but also receptor-interacting serine/threonine kinase (RIPK)1-dependent necroptosis in auditory cells. We observed the ultrastructural characteristics of both apoptosis and necroptosis in tunicamycin-treated cells under transmission electron microscopy (TEM).
View Article and Find Full Text PDFArticle Synopsis
- Patients with tongue cancer often experience loss of the von Hippel-Lindau (VHL) tumor suppressor gene, but the expression of its protein (pVHL) in tongue cancer has not been well studied.
- A study analyzed pVHL expression in tongue cancer tissues from 19 patients, revealing varied results regarding loss of heterozygosity (LOH) and differing staining patterns between well-differentiated and poorly differentiated cancer cells.
- The presence of pVHL was noted in both cancerous areas and dysplastic lesions, indicating it could serve as a valuable marker for identifying proliferative lesions in the tongue.