Publications by authors named "Miyoko Hasebe"
Introduction: Zonisamide is a medication developed in Japan that is effective for motor symptoms and wearing off in Parkinson's disease (PD). Zonisamide has properties that may improve sleep disorders. The aim of this study is to verify the safety and efficacy of zonisamide for sleep disorders and rapid eye movement (REM) sleep behavioral disorders (RBD) using a mobile two-channel electroencephalography /electrooculography recording system in patients with PD.
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- Sleep disorders are common in Parkinson's disease, but treatment options, like dopaminergic agents, have uncertain effectiveness, leading to this study on zonisamide's effects.
- The study is a randomized, placebo-controlled trial where 25 mg of zonisamide is given nightly for 28 days to evaluate improvements in sleep quality and REM sleep behavior in Parkinson's patients.
- The research involves analyzing sleep data through a portable EEG/EOG system before and after the treatment, with the study protocol approved by relevant medical review boards and registered with clinical trial authorities.