Publications by authors named "Miyazaki D"
1,1-Difluoroallenes underwent regioselective [2 + 2] and [3 + 2] cycloadditions with aldehydes using Au(I) catalysts. An AuCl catalyst enabled an α,β-selective [2 + 2] cycloaddition of 1,1-difluoroallenes, yielding ()-3-alkylidene-2,2-difluorooxetanes. Conversely, an AuCl(IPr)-AgSbF catalyst facilitated an α,γ-selective [3 + 2] cycloaddition, followed by dehydrofluorination to produce aromatized 2-fluorofurans.
View Article and Find Full Text PDFWe developed an AI system capable of automatically classifying anterior eye images as either normal or indicative of corneal diseases. This study aims to investigate the influence of AI's misleading guidance on ophthalmologists' responses. This cross-sectional study included 30 cases each of infectious and immunological keratitis.
View Article and Find Full Text PDFBackground: Intensified systemic chemotherapy following minimally invasive surgery for patients with unresectable metastatic colorectal cancer is performed to achieve curative resection and improve quality of life. We report a case of initially unresectable rectal cancer with metastases treated with laparoscopic and thoracoscopic staged resections after triplet chemotherapy plus bevacizumab.
Case: A 71-year-old man was referred to our hospital to examine the cause of constipation.
Article Synopsis
- The study aimed to compare the effectiveness of iodine compounds and levofloxacin in cleaning the conjunctival sac after cataract surgery.
- It involved 128 patients who received either levofloxacin or diluted iodine drops for a week after surgery, with bacterial cultures taken before surgery and at one and two months post-op.
- Results showed that both treatments reduced bacterial contamination initially, but levofloxacin was more effective in reducing bacterial DNA; however, it also led to the emergence of more resistant bacteria over time, unlike the iodine treatment.
Article Synopsis
- Artificial intelligence shows potential for diagnosing allergic conjunctival diseases (ACDs), but its development is hindered by a lack of tailored image databases and model explainability.
- This study utilized a dataset of 4,942 slit-lamp images from 10 institutions in Japan to create an AI model that diagnoses ACDs and explains its reasoning.
- Results indicated the AI model achieved a diagnostic accuracy of 86.2%, significantly outperforming board-certified ophthalmologists, and demonstrated effective identification of key clinical indicators for various ACDs.
Background/aim: Laparoscopic anatomical liver resection (LAR) for hepatocellular carcinoma (HCC) is technically demanding. Therefore, this study aimed to compare the perioperative and long-term oncological outcomes of LAR and open anatomical liver resection (OAR) for HCC.
Patients And Methods: We retrospectively analyzed 460 consecutive patients who underwent anatomical liver resection as the initial treatment for primary HCC between January 2010 and February 2024.
Background/aim: This study aimed to characterize intraductal papillary neoplasm of the bile duct (IPNB) in patients undergoing initial and recurrent surgical resection and to evaluate the appropriateness of surgical treatment strategies.
Patients And Methods: This study included 14 patients who underwent liver resection for intrahepatic IPNB. We assessed intraoperative and postoperative clinicopathological factors in patients undergoing both initial and recurrent surgeries.
Article Synopsis
- The study evaluates the HALP score, an immune-nutritional assessment, as a way to predict survival outcomes in patients post-surgery for liver cancer (hepatocellular carcinoma).
- Analyzing data from 685 patients who had surgery, the researchers found that lower HALP scores linked to worse overall survival, but did not significantly affect recurrence-free survival or post-op results.
- The conclusion suggests that the HALP score is a practical and cost-effective method to predict prognosis for these patients after liver surgery.
Article Synopsis
- The study aimed to evaluate how well contrast-enhanced computed tomography (CECT) predicts outcomes for patients with severe acute pancreatitis (SAP) by using the computed tomography severity index (CTSI).
- A retrospective analysis of 1,097 SAP patients from 44 institutions in Japan found that while necrosis in pancreatic tissue increased mortality risks, the overall inflammation did not significantly impact mortality rates.
- The results showed that the CTSI had a moderate ability (AUC 0.65) to predict mortality, with significant correlations between higher levels of pancreatic necrosis and increased odds of death.
Purpose: To determine whether there is a significant association between inflammatory cytokines in the tear fluid and the severity of Retinopathy of Prematurity (ROP).
Study Design: Retrospective cohort study.
Methods: The cytokine levels in tear fluids were determined in 34 eyes with ROP and 18 eyes without ROP.
Purpose: Operations for malignant diseases of the bile duct, pancreas, and esophagus are the most invasive gastroenterological surgeries. The frequency of complications after these surgeries is high, which affects the postoperative course and mortality. In patients who undergo these types of surgeries, continuous monitoring of the perioperative central venous oxygen saturation (ScvO) is possible via a central venous catheter.
View Article and Find Full Text PDFObjectives: Deep pelvic abscesses are surrounded by the pelvic bones, bladder, gynecological organs, intestinal tract, and nerve and vascular systems, and are approached by various routes for drainage. The transgluteal approach is often performed under computed tomography guidance; however, if ultrasonography can be used to confirm the approach, it is considered more effective because it reduces radiation exposure and allows for real-time puncture under sonographic and fluoroscopic guidance.
Methods: This retrospective study was conducted at Tobata Kyoritsu Hospital (Fukuoka, Japan) between April 1, 2021, and December 31, 2022.
Article Synopsis
- Short bowel syndrome (SBS) can develop after acute aortic dissection, leading to chronic intestinal failure that requires home parenteral nutrition; Teduglutide (TED) is a drug that helps improve intestinal absorption and quality of life for these patients.* -
- A case study of a 68-year-old man who had massive intestinal surgery shows he developed gastric mucosal necrosis after receiving TED, despite initial improvement in his nutritional status through enteral feeding.* -
- The effectiveness of TED in patients with SBS who also have multiple organ failure is uncertain, suggesting that its use should be carefully evaluated in cases of uncontrolled systemic infection.*
Article Synopsis
- The study investigates two aggressive types of hepatocellular carcinoma (HCC): macrotrabecular massive (MTM) pattern and vessels encapsulating tumor clusters (VETC) pattern, focusing on their immunophenotypes and tumor immune microenvironment (TIME).
- It analyzes 74 cases of previously diagnosed HCC, revealing that MTM-HCC has distinct characteristics, including higher PD-L1 expression (associated with immune suppression) compared to VETC-HCC and conventional HCC.
- Findings suggest that although both patterns exhibit an immunosuppressive TIME, they consist of different elements, and transitioning TIME from suppressive to active could improve the efficacy of immune checkpoint inhibitors in treatment.
Article Synopsis
- Atopic conditions, particularly atopic dermatitis (AD), are linked to a higher incidence and severity of HSV keratitis among patients with ocular infections.
- The study revealed that patients with AD experienced a significantly greater proliferation of HSV and a higher likelihood of recurrence compared to those without atopic conditions.
- Factors including non-infectious atopic blepharitis and asthma were particularly influential in increasing the risk of recurrent HSV keratitis.
A 67-year-old male was referred to our hospital in a state of shock. Transcatheter arterial embolization(TAE)was performed for the diagnosis of liver tumor rupture, followed by extended posterior area resection 18 days later. Histopathologically, he was diagnosed with hepatic angiosarcoma.
View Article and Find Full Text PDFBackground: spp. is associated with fulminant sepsis, particularly in those with immunosuppression. We here report a rare case of fatal fulminant septic shock caused by , concurrent with COVID-19.
View Article and Find Full Text PDFEfficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1.
Mol Ther Nucleic Acids
December 2023
Article Synopsis
- Exon-skipping therapy is a potential treatment for Duchenne muscular dystrophy (DMD) by targeting specific exons in the dystrophin gene, particularly focusing on a mild variant known as Δ3-9.
- A study compared human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with either the Δ3-9 deletion, a frameshifting deletion (Δ3-7), or intact dystrophin, revealing that the Δ3-9 variant mimicked the expression patterns and electrical properties of healthy heart cells.
- Antisense oligonucleotides targeting exon 8 successfully restored functional dystrophin and improved cell characteristics in the Δ3-7 cells, suggesting that modifying
Purpose: To estimate the roles of extracellular vesicles (EVs) in tears and to determine whether their profiles are associated with the type of ocular disease.
Study Design: Cross-sectional study.
Methods: Tear EVs were extracted from 14 healthy participants and from 21 patients with retinal diseases (age-related macular degeneration [AMD] or diabetic macular edema [DME]).
Article Synopsis
- - This study investigates the clinical aspects of Becker muscular dystrophy (BMD), a milder form of Duchenne muscular dystrophy (DMD), focusing on muscle, respiratory, cardiac, and central nervous system involvement in 225 patients.
- - Most patients presented initial muscular symptoms, with gait disturbances noted in over half, and a small percentage requiring ventilators or showing heart complications, with specific genotype correlations found.
- - The findings are significant for guiding treatment and preventive measures for BMD, offering crucial insights for both patients and healthcare professionals.
Objectives: Patients with systemic vasculitis may develop myalgia as an initial symptom. However, the immunopathology of vasculitic myopathy remains unclear. We investigated the immunopathological features of skeletal muscle in small-to-medium-sized vessel vasculitis.
View Article and Find Full Text PDFAims: Heart failure is a significant disease, and its high readmission rate is a big concern. We must identify readmission risk factors and optimize outpatient management to prevent them. This study aims to investigate the readmission risk factors, including outpatient management represented by the number of outpatient visits, and to identify the factors related to frequent outpatient visits.
View Article and Find Full Text PDFIntroduction: Dupilumab is a drug that inhibits the action of interleukin (IL)-4 and IL-13 and is a potent therapeutic drug for allergic diseases such as atopic dermatitis. Although its use has been associated with significant ocular adverse drug reactions (ADRs), the IL-4 and IL-13 inhibition may also have favorable therapeutic effects. The aim of this study was to determine the disease spectrum in which the use of dupilumab may have been associated with an increase or decrease of ocular ADRs.
View Article and Find Full Text PDFPurpose: To determine the effect of the formulation of topical medications on the healing of corneal epithelial cells after phototherapeutic keratectomy (PTK).
Study Design: Retrospective cohort study.
Methods: We studied 271 eyes of 189 consecutive patients (aged 67.