Publications by authors named "Miyaka Wada"
Impact of Chronic Kidney Disease on the Associations of Cardiovascular Biomarkers With Adverse Outcomes in Patients With Suspected or Known Coronary Artery Disease: The EXCEED-J Study.
J Am Heart Assoc
February 2022
Background The impact of chronic kidney disease (CKD) on the prognostic utility of cardiovascular biomarkers in high-risk patients remains unclear. Methods and Results We performed a multicenter, prospective cohort study of 3255 patients with suspected or known coronary artery disease (CAD) to investigate whether CKD modifies the prognostic utility of cardiovascular biomarkers. Serum levels of cardiovascular and renal biomarkers, including soluble fms-like tyrosine kinase-1 (sFlt-1), N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin-I (hs-cTnI), cystatin C, and placental growth factor, were measured in 1301 CKD and 1954 patients without CKD.
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- The study investigates how smoking influences levels of growth differentiation factor 15 (GDF-15) and its relationship to mortality in patients with coronary artery disease.
- Among 2,418 patients, never smokers had lower GDF-15 levels compared to former and current smokers, and high GDF-15 levels were linked to increased all-cause mortality across all smoking statuses.
- GDF-15's predictive value regarding mortality was most relevant for never smokers, suggesting that smoking history affects its prognostic utility in this patient population.
Background VEGF-D (vascular endothelial growth factor D) and VEGF-C are secreted glycoproteins that can induce lymphangiogenesis and angiogenesis. They exhibit structural homology but have differential receptor binding and regulatory mechanisms. We recently demonstrated that the serum VEGF-C level is inversely and independently associated with all-cause mortality in patients with suspected or known coronary artery disease.
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