Publications by authors named "Miyabi Suzuki"
Article Synopsis
- The Hippo pathway is essential for regulating cell growth and differentiation, playing a key role in tumor development and embryonic formation.
- Scaffold proteins from the ERM family, particularly NF2 (Merlin), influence this pathway through cell polarity, but how this works for outer cell establishment is not fully understood.
- This study created specific Nf2 mutants to investigate its impact on YAP1 localization, revealing that NF2's positioning around the cell membrane affects cell polarity and the Hippo pathway's function by regulating the placement of proteins like LATS2 and ezrin.
Evaluation of the safety of time-lapse observations for human embryos.
J Assist Reprod Genet
February 2010
Purpose: To assess the effects of light from an integrated optical microscope and evaluate the safety of time-lapse observations using a built-in microscope incubator.
Methods: We prospectively compared the fertilization rate and embryonic morphology after intracytoplasmic sperm injection between embryos cultured with time-lapse observations every 15 min in an incubator with an integrated optical microscope and embryos with intermittent observations (once a day) in conventional incubators.
Results: No significant differences were observed in the fertilization rate (57.
When human blastocysts hatch through the zona pellucida, gaining the ability to adhere to the endometrium, crosstalk between the embryo and the uterus may represent a successful outcome of their synchronized development and differentiation. CD26/dipeptidyl peptidase IV is known as a marker molecule of the implantation phase endometrium. To study the role of CD26 in implantation, 35 human hatched blastocysts were prepared by enzymatic treatment of expanded blastocysts that had been grown on schedule from frozen-thawed surplus embryos at the 2- or 4-cell stage.
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