Publications by authors named "Miwako Shikina"
To investigate the effects of growth (organ development) on tetrodotoxin (TTX) dynamics in the pufferfish body, TTX-containing feed homogenate was administered to 6- and 15-month old non-toxic cultured specimens of the pufferfish Takifugu rubripes at a dose of 40 mouse units (MU) (8.8 μg)/20 g body weight by oral gavage. After 24 h, the specimens were killed and the skin tissues (dorsal and ventral), muscle, liver, digestive tract, and gonads were separated.
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- Research on the goby fish Yongeichthys criniger revealed that tetrodotoxin (TTX) distribution changes with maturation in female specimens collected over two time periods (2008-2010) in Okinawa, Japan.
- The study identified different reproductive phases and found that TTX levels peaked in the ovary during the spawning period, suggesting that this fish accumulates TTX significantly in its reproductive organs.
- Additionally, in a different group of specimens, TTX was mostly found in the skin during early maturation stages, but as the ovaries matured, TTX levels in the ovaries increased notably, especially in the later stages of yolk development.