Publications by authors named "Miwako Sase"
Article Synopsis
- The study investigates the cause of tongue cancer relapse post-chemotherapy, focusing on minimal residual disease (MRD) that consists of surviving cancer cells.
- The researchers developed tongue cancer organoids from 28 untreated patients, which mimicked tumor behavior and displayed chemo-resistance after cisplatin treatment.
- Key findings indicate that targeting specific biological pathways, such as autophagy and cholesterol synthesis, can convert chemo-resistant cells to chemo-sensitive ones, presenting new strategies to prevent recurrence in tongue cancer.
The small intestine has a robust regenerative capacity, and various cell types serve as "cells-of-origin" in the epithelial regeneration process after injury. However, how much each population contributes to regeneration remains unclear. Using lineage tracing, we found that Lgr5-expressing cell derivatives contained radioresistant intestinal stem cells (ISCs) crucial for epithelial regeneration in the damaged intestine after irradiation.
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