Publications by authors named "Miwa Ito"
Landiolol, an ultra-short-acting β1-selective blocker, is more effective in controlling heart rate compared with digoxin in patients with atrial tachyarrhythmias and left ventricular dysfunction. However, the effect of atrial tachyarrhythmia type on the effectiveness of landiolol remains unknown. Hence, this study aimed to evaluate the effectiveness of landiolol in patients with atrial fibrillation (AF) and atrial tachycardia (AT), not limited to those with heart failure with a reduced ejection fraction.
View Article and Find Full Text PDFAims: Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is often accompanied by atrial fibrillation (AF), atrial flutter (AFL), and atrial tachycardia (AT), which are difficult to control because beta-blockers and antiarrhythmic drugs can worsen heart failure (HF). This study aimed to investigate the outcomes of catheter ablation (CA) for AF/AFL/AT in patients with ATTRwt-CM and propose a treatment strategy for CA.
Methods And Results: A cohort study was conducted on 233 patients diagnosed with ATTRwt-CM, including 54 who underwent CA for AF/AFL/AT.
Neither the efficacy nor safety of elobixibat has been investigated in the treatment of chronic constipation in patients with heart failure (HF). In this prospective, single-center, single-arm study elobixibat (10 mg/day) was administered for 12 weeks to 18 HF patients with chronic constipation defined according to the Rome IV criteria. Spontaneous bowel movement (SBM), stool consistency as measured by the Bristol Stool Form Scale, and degree of straining during defecation were recorded.
View Article and Find Full Text PDFSpinocerebellar ataxia type 14 (SCA14) is a rare form of autosomal dominant cerebellar ataxia caused by mutations in PRKCG. We herein report a case of SCA14 presenting with writer's cramp that predated the onset of progressive ataxia by four years. A 47-year-old Japanese woman had an 11-year history of writer's cramps, followed by unsteadiness.
View Article and Find Full Text PDFBackground: Patients with acute myocardial infarction (AMI) complicating renal dysfunction (RD) are recognized as being at high risk. Although diabetes mellitus (DM) is a major cause of RD, the prognostic impact of coexisting DM on mortality in patients with AMI complicating RD is ill-defined. This study compared the prognostic impact of coexisting DM in patients with AMI complicating RD according to both age and sex.
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- The study investigated the role of integrin α in liver fibrosis, particularly in a rat model of nonalcoholic steatohepatitis (NASH).
- Researchers used a radiotracer called [F]F-FPP-RGD to assess integrin α levels and liver function, finding that integrin α siRNA reduced its protein levels in a dose-dependent manner.
- The results indicated that [F]F-FPP-RGD PET imaging could effectively monitor integrin α levels and liver health in NASH, providing potential for future diagnostic applications.
Article Synopsis
- The study investigates factors that indicate the need for pacing device implantation (PDI) in patients with transthyretin amyloid cardiomyopathy (ATTR-CM), aiming to determine the role of preventive PDI and implantable cardioverter-defibrillator (ICD) implantation.
- It involved analyzing data from 114 wild-type and 50 hereditary ATTR-CM patients who were not implanted with pacing devices at diagnosis, comparing backgrounds of those who needed future PDI and identifying specific conduction disturbances linked to these needs.
- Findings suggest that bifascicular block is a significant predictor for PDI in both types of ATTR-CM, while first-degree AV block does not necessitate PDI or ICD; the need for larger studies is
Article Synopsis
- The study investigates the relationship between Japanese high bleeding risk criteria (J-HBR), thrombogenicity, and bleeding events in patients undergoing percutaneous coronary intervention (PCI) through a retrospective analysis of 300 patients.
- It categorizes patients into three groups based on their J-HBR status and finds that a high J-HBR score is linked to lower thrombogenicity and an increased incidence of bleeding events within a year.
- The findings suggest that a J-HBR-positive/high status indicates both low thrombus formation and a higher risk of bleeding complications post-PCI.
Article Synopsis
- The study investigates the "obesity paradox," where overweight/obesity is linked to both improved and worsened survival outcomes in heart failure (HF) and coronary artery disease (CAD), particularly among patients with acute myocardial infarction (AMI).
- It analyzed data from 7,265 AMI patients, categorizing HF severity using the Killip classification and found that overweight/obesity decreased in-hospital mortality for patients with mild HF but increased risk for those with severe HF.
- The results highlight that the impacts of overweight/obesity vary significantly with HF severity, pointing toward a negative effect as HF worsens, indicating a need for careful management of weight in these patients.
Article Synopsis
- Alcohol is a known risk factor for atrial fibrillation (AF), and variants of the aldehyde dehydrogenase 2 (ALDH2) gene, which affect alcohol metabolism, are common among East Asians.
- A study investigated the link between AF and ALDH2 variants in 656 patients, finding that those with the deficient variant who consumed alcohol had a significantly higher risk of developing AF.
- The results suggested that while the ALDH2 variant itself was not directly linked to AF incidence, carriers who habitually consumed alcohol faced increased risk, indicating that avoiding alcohol may help prevent AF in these individuals.
Background: A three-dimensional (3D) mapping system is essential to reduce radiation exposure during catheter ablation. When using the CARTO 3D mapping system, only the catheter with magnetic sensor can visualize its location. However, once target chamber matrix is created using the catheter, even the catheters without magnetic sensors (CWMS) can enable visualization.
View Article and Find Full Text PDFUsefulness of F-FPP-RGD PET in pathophysiological evaluation of lung fibrosis using a bleomycin-induced rat model.
Eur J Nucl Med Mol Imaging
November 2022
Purpose: Integrins α are key molecules in the pathogenesis of fibrosis in multiple organs. To assess the potential utility of integrin αβ imaging for idiopathic pulmonary fibrosis (IPF), we evaluated an F-FPP-RGD PET probe in a rat model of bleomycin-induced lung fibrosis.
Methods: Pulmonary fibrosis was induced by single intratracheal instillation of bleomycin (3 mg/rat).
Hepatic surgery is a rapidly expanding component of abdominal surgery and is performed for a wide range of indications. The introduction of laparoscopic cholecystectomy in 1987 was a major change in abdominal surgery. Laparoscopic surgery was widely and rapidly adopted throughout the world for cholecystectomy initially and then applied to a variety of other procedures.
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- The study investigates the link between malnutrition, thrombogenicity, and bleeding events in coronary artery disease patients who undergo a procedure called percutaneous coronary intervention (PCI).
- It analyzes data from 300 patients, categorizing them based on their nutritional status using the geriatric nutritional risk index (GNRI) and assesses bleeding risk over a year using specific criteria.
- Findings show that malnourished patients (lower GNRI) have lower thrombus formation and higher chances of bleeding events compared to well-nourished patients, highlighting the importance of nutritional status in predicting complications after PCI.
Background/aims: The Heart Failure Association (HFA)-PEFF score is recognized as a simple method to diagnose heart failure (HF) with preserved ejection fraction (HFpEF). This study aimed to evaluate the relationship between HFA-PEFF scores and cardiovascular outcomes in HFpEF patients.
Methods: A total of 502 consecutive HFpEF patients were prospectively observed for up to 1,500 days.
Article Synopsis
- The study investigates the relationship between soluble PD-L1 (sPD-L1) levels and acute coronary syndrome (ACS) in patients with coronary artery disease (CAD).
- Researchers found that sPD-L1 levels were significantly higher in ACS patients compared to those with chronic coronary syndrome (CCS) and non-CAD patients (ACS: 188.7 pg/mL vs. non-CAD: 83.5 pg/mL and CCS: 144.2 pg/mL).
- The study concluded that elevated sPD-L1 levels are strongly and independently associated with ACS, marking a significant finding in understanding cardiac health and immune response.
Article Synopsis
- - The study aimed to investigate whether royal jelly, a substance from honeybees, impacts vascular endothelial function (a marker for early atherogenesis) in healthy individuals, focusing on its potential benefits against dyslipidemia and metabolic syndrome.
- - Conducted as a double-blind, placebo-controlled trial with 100 healthy participants, the research found that those taking royal jelly showed a significant improvement in vascular function (measured by the RH-PAT index) and better liver function results compared to the placebo group after 4 weeks.
- - The findings suggest that royal jelly may possess antiatherogenic properties by enhancing vascular health and improving liver function, though it did not significantly alter lipid profiles in participants.
Background: Although the Khorana venous thromboembolism (VTE) risk score (KRS) is well recognized as a simple VTE risk assessment method in patients with cancer, whether it is suitable for Asian populations is unclear.
Objectives: This study validated KRS for the prediction of VTE and investigated the value of the KRS in predicting mortality in Japanese patients with cancer.
Methods: A body mass index value of 25 kg/m or more was defined as obesity according to World Health Organization consensus.
Background The clinical implication of vascular endothelial dysfunction in patients with atrial fibrillation (AF) remains unclear. This study aimed to elucidate the correlation between changes in vascular endothelial function assessed by reactive hyperemia-peripheral arterial tonometry and the effect of sinus rhythm restoration after catheter ablation (CA) for AF. Methods and Results Consecutive 214 patients who underwent CA for AF were included in this single center, retrospective study.
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- The text indicates a correction to a previously published article, identified by its DOI (Digital Object Identifier) 10.1253/circrep.CR-19-0117.
- The correction likely addresses errors or inaccuracies found in the original article.
- This is important for maintaining the integrity and accuracy of academic literature, ensuring readers have the most reliable information.
Article Synopsis
- Epithelial ovarian cancer (EOC) is the deadliest form of gynecologic cancer, primarily due to high rates of recurrence linked to hidden metastasis.
- Research shows that plasma-activated medium (PAM) can significantly inhibit the spread of ovarian cancer both in lab settings and animal models.
- The study reveals that PAM stimulates an immune response by attracting macrophages, which may help combat tumors, and demonstrates its potential benefits in improving survival rates in mouse models of ovarian cancer, indicating possible clinical applications.