Publications by authors named "Miwa Akutsu"
Article Synopsis
- Synovial fibroblasts and T cells contribute to chronic inflammation in the temporomandibular joint (TMJ) through a feedback loop involving cytokines like IL-17.
- A study focused on IL-17A showed that it enhances the expression of inflammatory cytokines, particularly IL-6, in synovial fibroblasts from patients with TMJ disorders.
- The mechanism by which IL-17A increases IL-6 production involves specific signaling pathways, including NFκB and PI3K/Akt, indicating a strong link between IL-17A and inflammation in TMJ disorders.
Background: Primary frozen shoulder (FS) is a painful contracture of the glenohumeral joint that arises spontaneously without an obvious preceding event. Investigation of the intra-articular and periarticular pathology would contribute to the treatment of primary FS.
Review Of Literature: Many studies indicate that the main pathology is an inflammatory contracture of the shoulder joint capsule.
Total hip/knee arthroplasty may cause venous thromboembolism (VTE) as a postoperative complication. However, there are few reports on VTE after arthroscopic shoulder surgery. We report a patient who developed pulmonary embolism (PE) 6 days after arthroscopic rotator cuff repair but recovered without sequelae.
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- Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain and inflammation, but their specific effects on inflammation in the temporomandibular joint (TMJ) remain unclear, prompting this study.
- The research involved obtaining human synovial tissue from patients and testing how COX inhibitors like indomethacin and celecoxib affect the production of inflammatory markers in fibroblast-like synoviocytes (FLS) under different conditions.
- Results showed that COX inhibitors effectively reduced the levels of harmful inflammatory substances (COX-2 and IL-6) in FLS and identified EP2 and EP4 as key receptors that PGE2 interacts with, highlighting a potential pathway for NSAID effectiveness in
Background: Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are key mediators of the intracapsular pathological conditions of the temporomandibular joint (TMJ). Therefore, the gene expression profiles in synovial fibroblast-like cells (SFCs) from patients with internal derangement of the TMJ were examined after they were stimulated with IL-1β or TNF-α to determine which genes were altered.
Methods: Ribonucleic acid was isolated from SFCs after IL-1β or TNF-α treatment.
Background: Interleukin (IL)-1beta is thought to play a key role in several pathologic conditions of the temporomandibular joint (TMJ). Gene expression profile of synovial fibroblasts stimulated with IL-1beta was studied by oligonucleotide microarray analysis to elucidate candidate genes associated with intracapsular pathologic conditions of TMJ.
Methods: RNA was isolated from synovial fibroblasts from five patients after IL-1beta treatment.