Publications by authors named "Miu Sakurai"
Article Synopsis
- Calcium oscillations are crucial for fully activating oocytes during mammalian fertilization, and sperm-specific phospholipase C (PLCζ) is vital for inducing these oscillations; mutations in PLCζ can lead to male infertility.
- Sperm lacking PLCζ can induce some calcium rises after IVF but not during intracytoplasmic sperm injection (ICSI), resulting in poor development of oocytes in ICSI situations.
- Additional treatments, such as injecting PLCζ mRNA or applying SrCl, significantly improve pronuclear formation and development to the two-cell stage in oocytes injected with PLCζ-deficient sperm, leading to the production of healthy pups after embryo transfer.
