Publications by authors named "Mitzzy F Medellin-Luna"
Fluoroquinolone Analogs, SAR Analysis, and the Antimicrobial Evaluation of 7-Benzimidazol-1-yl-fluoroquinolone in In Vitro, In Silico, and In Vivo Models.
Molecules
August 2023
Article Synopsis
- Structure-activity relationship (SAR) studies help understand how changes in chemical structure affect biological activity, specifically in fluoroquinolones, which can be modified to create new antibacterial analogs.
- The research aimed to find a C-7 heterocycle fluoroquinolone analogue with similar antibacterial effects as a reference fluoroquinolone through a series of experiments, including in vitro, in silico, and in vivo evaluations.
- The study identified 7-benzimidazol-1-yl-fluoroquinolone as the most effective compound against various bacteria, showing no cytotoxicity to non-bacterial cells and successfully reducing bacteria in infected wound tissue in a mouse model.
Methotrexate reduces keratinocyte proliferation, migration and induces apoptosis in HaCaT keratinocytes in vitro and reduces wound closure in Skh1 mice in vivo.
J Tissue Viability
February 2021
The aim of the present work was to evaluate MTX treatment (0.1, 1 and 10 μg mL) in vitro in order to characterize its effects on cell proliferation alterations in cell cycle of HaCaT keratinocytes and wound healing in a Skh1 mice treated with MTX (low doses 30 mg kg, high doses 200 mg kg and repeated doses at 1.5 mg kg).
View Article and Find Full Text PDFSkin insult and damage start a complex healing process that involves a myriad of coordinated reactions at both the cellular and molecular level occurring simultaneously. These processes can be divided into that of cell migration and tissue remodeling of the wound. In addition, it is well known that deep wounds that derive from surgical procedures need a multidisciplinary approach to have a successful wound healing process.
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