Publications by authors named "Mittag N"
Article Synopsis
- Immune checkpoint inhibitors can cause immune-related lichenoid skin reactions (irLP) that are often hard to treat, and this study aims to compare these reactions to spontaneous lichen planus (LP).
- The research found that irLP and LP have different clinical and histological characteristics, with irLP showing a more widespread rash and a unique inflammatory gene profile, indicating different underlying mechanisms.
- The results suggest that topical JAK inhibitors might be a promising treatment for irLP due to its distinct inflammatory signature, although further studies with larger groups are needed for confirmation.
Pigmentation is an important process in skin physiology and skin diseases and presumably also plays a role in Parkinson's disease (PD). In PD, alpha-Synuclein (aSyn) has been shown to be involved in the pigmentation of neurons. The presynaptic protein is intensively investigated for its pathological role in PD, but its physiological function remains unknown.
View Article and Find Full Text PDFStatins (3-hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase inhibitors) are well-established agents to treat hyperlipidemic states. Experimental and epidemiological evidence further implies an anticancer effect of these substances. This study investigates the mechanism underlying human lung cancer cell death by lovastatin and the role of the prostaglandin (PG)-synthesizing enzyme cyclooxygenase-2 (COX-2) in this process.
View Article and Find Full Text PDFA Case Report of a Carbamazepine Overdose With Focus on Pharmacokinetic Aspects.
Pharmacopsychiatry
March 2016
In this article a case of carbamazepine overdose is reported. It is common to use immuno-based methods in the field of therapeutic drug monitoring but it might be difficult to adapt such values to toxicological cases. For carbamazepine overdoses it is recommended also to determine the metabolite carbamazepine-10,11-epoxide.
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