Publications by authors named "Mitsutaka Nakashima"
Unlabelled: An 82-year-old man with a secundum atrial septal defect (ASD) underwent transcatheter closure. The patient had a wide area of aortic and superior rim deficiency, with left ventricular diastolic dysfunction and moderate mitral regurgitation. These findings suggested the risk of both cardiac erosion and increased left atrial pressure after closure.
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- The study examines the differences in patent foramen ovale (PFO) morphologies between older patients (≥60 years) and younger patients (<60 years) who have experienced cryptogenic ischemic strokes (CS).
- Results show that older patients had a significantly higher prevalence of atrial septal aneurysm and more frequent septal malalignment, while other high-risk PFO features were similarly present in both age groups.
- Overall, nearly 90% of older patients with PFO were classified as having a 'possible' link to their stroke, indicating that high-risk PFO morphologies are common across different age demographics.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the proposed name change for non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the association of cardiovascular disease risk with MASLD and NAFLD in patients who underwent clinically indicated coronary computed tomography angiography (CCTA).
Methods: This retrospective study included 2289 patients (60% men; mean age: 68 years) with no history of coronary artery disease who underwent CCTA.
Objective: To investigate the diagnostic performance of a calcium-removal image reconstruction algorithm with photon-counting detector-computed tomography (PCD-CT), a technology that hides only the calcified plaque from the spectral data in coronary calcified lesions.
Methods: This retrospective study included 17 patients who underwent PCD-coronary CT angiography (CCTA) with at least one significant coronary stenosis (≥50 %) with calcified plaque by CCTA and invasive coronary angiography (ICA) performed within 60 days of CCTA. A total of 162 segments with calcified plaque were evaluated for subjective image quality using a 4-point scale.
Article Synopsis
- - Transcatheter closure of patent foramen ovale (PFO) is a common method to prevent paradoxical embolism, but it can lead to residual shunt, increasing the risk of stroke.
- - A study examined the anatomical features of PFO in 106 patients to understand the occurrence of residual shunts after closure, finding that 28 patients had some degree of residual shunt post-procedure.
- - The presence of an atrial septal aneurysm (ASA) was significantly linked to residual shunts, while other factors like PFO size and closure device size did not show a strong relationship, except in a few cases of device size mismatch.
Pulmonary arterial hypertension is a life-threatening disease that coexists with right heart failure. We evaluated the relationship between malnutrition and prognosis in patients with pulmonary arterial hypertension, as malnutrition is known as a prognosis determinant in chronic heart failure. We retrospectively reviewed data of patients with pulmonary arterial hypertension before treatment.
View Article and Find Full Text PDFAims: Heart failure with a preserved ejection fraction (HFpEF) is associated with chronic inflammation. We aimed to investigate the association between pericoronary adipose tissue attenuation (PCATA) on coronary computed tomography angiography as a novel noninvasive marker of pericoronary inflammation and the presence of HFpEF.
Methods And Results: This retrospective study included 607 outpatients (median age, 65 years; 50% male) who underwent both echocardiography and coronary computed tomography angiography.
Primary cardiac sarcomas are rare diseases with very poor prognoses. In this report, we present a case of coronary artery intimal sarcoma in a patient who survived for a long time after diagnosis. A 57-year-old female underwent percutaneous coronary intervention of the right coronary artery due to acute myocardial infarction caused by thrombotic occlusion and was diagnosed as having coronary artery intimal sarcoma.
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- * In a retrospective study involving 113 patients, researchers found that a lower FIB5 was linked to a higher incidence of major adverse cardiovascular events (MACEs) over a median follow-up of 3 years.
- * While both FIB4 and FIB5 showed similar prognostic values overall, FIB5 outperformed FIB4 in predicting outcomes specifically for patients under 70 years old.
Article Synopsis
- A 46-year-old woman with a history of thromboembolic stroke was misdiagnosed with patent foramen ovale after saline contrast echocardiography showed microbubbles in her left atrium.
- Further tests, including transesophageal echocardiography and contrast CT, revealed the presence of a pulmonary arteriovenous malformation (AVM) in her upper left lung lobe instead.
- This case highlights the need for careful diagnosis of pulmonary AVMs, as they can mimic the symptoms of patent foramen ovale, especially when microbubbles appear in the left atrium rapidly.
Cardiovascular diseases and liver diseases are closely related. Non-alcoholic fatty liver disease has the same risk factors as those for atherosclerotic cardiovascular disease and may also be a risk factor for atherosclerotic cardiovascular disease on its own. Heart failure causes liver fibrosis, and liver fibrosis results in worsened cardiac preload and congestion.
View Article and Find Full Text PDFThe triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is an independent risk index for cardiovascular events. This study aimed to evaluate the association between TG/HDL-C ratio and coronary plaque characteristics as seen on coronary computed tomography angiography (CCTA) and the corresponding increase in the likelihood of cardiovascular events. A total of 935 patients who underwent CCTA for suspected coronary artery disease (CAD) were included.
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- * After the second treatment, he developed fever and fatigue, with lab tests revealing heart damage and a biopsy confirming myocarditis as an immune-related adverse event.
- * Despite receiving high-dose corticosteroids, his condition deteriorated rapidly, resulting in his death five days later, highlighting the need for effective treatment options for severe myocarditis arising from cancer immunotherapy.
Background: The fibrosis-4 (FIB-4) index is used to evaluate liver disease patients. It can also be used to evaluate the prognosis for heart disease patients; however, its ability to determine the prognosis of severe isolated tricuspid regurgitation (TR) patients is unclear. This study aimed to clarify the association between FIB-4 index scores and the cardiovascular prognosis for severe isolated TR patients.
View Article and Find Full Text PDFBackground: Impaired high-density lipoprotein (HDL) function is a risk factor for cardiac mortality. We aimed to investigate the association between oxidized HDL (oxHDL) and pericoronary adipose tissue (PCAT) attenuation, a novel imaging biomarker of pericoronary inflammation, by using coronary computed tomography angiography (CTA).
Methods: A total of 287 outpatients with suspected coronary artery disease who had undergone both oxHDL measurement and coronary CTA were examined.
Aims: Pericoronary adipose tissue (PCAT) attenuation on coronary computed tomography angiography (CTA) is a noninvasive biomarker for pericoronary inflammation and is associated with cardiac mortality. We aimed to investigate the association between PCAT attenuation and endothelial dysfunction assessed using flow-mediated dilation (FMD).
Methods: A total of 119 outpatients who underwent both coronary CTA and FMD measurements were examined.
Pericoronary adipose tissue (PCAT) attenuation on coronary computed tomography angiography (CTA) has been emerged as a marker of pericoronary inflammation. We aimed to investigate the prognostic value of PCAT attenuation in patients with non-alcoholic fatty liver disease (NAFLD). We enrolled 232 NAFLD patients with suspected coronary artery disease and underwent coronary CTA.
View Article and Find Full Text PDFNonalcoholic fatty liver disease (NAFLD) is a risk factor for the development of atherosclerotic cardiovascular diseases (CVDs), and oxidative stress has been proposed as a shared pathophysiological condition. This study examined whether oxidized low-density lipoprotein (LDL) is involved in the underlying mechanism that links coronary atherosclerosis and NAFLD. This study included 631 patients who underwent coronary computed tomography angiography (CTA) for suspected coronary artery disease.
View Article and Find Full Text PDFBackground: Pericoronary adipose tissue (PCAT) attenuation on coronary computed tomography angiography (CTA) is a non-invasive biomarker for pericoronary inflammation. We aimed to investigate the prognostic value of PCAT attenuation in patients with type 2 diabetes mellitus (T2DM).
Methods: We included 333 T2DM patients (mean age, 66 years; male patients, 211; mean body mass index, 25 kg/m) who underwent clinically indicated coronary CTA and examined their CT findings, coronary artery calcium score, pericardial fat volume, stenosis (> 50% luminal narrowing), high-risk plaque features of low-attenuation plaque and/or positive remodelling and/or spotty calcification, and PCAT attenuation.
Aims: Sodium glucose co-transporter 2 inhibitors have diuretic effects in both patients with glycosuria and with natriuresis. We sought to assess the effect of luseogliflozin on estimated plasma volume (ePV) in patients with type 2 diabetes and heart failure with preserved ejection fraction (HFpEF).
Methods And Results: This study was a post-hoc analysis of the MUSCAT-HF trial (UMIN000018395), a multicentre, prospective, open-label, randomized controlled trial that assessed the effect of 12 weeks of luseogliflozin (2.
Non-alcoholic fatty liver disease (NAFLD) is a risk factor for cardiac mortality. Pericoronary adipose tissue (PCAT) attenuation, expressed by the fat attenuation index on coronary computed tomography angiography, reflects pericoronary inflammation. We aimed to investigate the association between PCAT attenuation and NAFLD.
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