Publications by authors named "Mitsushi Yamamoto"
Bisphenol A alters sexual dimorphism and gene expression in marine medaka Oryzias melastigma.
Environ Sci Pollut Res Int
February 2023
Article Synopsis
- Bisphenol A (BPA) is found in both freshwater and marine environments and is known to disrupt endocrine systems, but its long-term toxicity in marine fish, specifically the male marine medaka, has not been fully established.
- In experiments, exposure to BPA led to the development of testis-ova and alterations in male anal fin shapes toward more female characteristics, indicating that anal fin shape is a particularly sensitive indicator of BPA exposure.
- The study also found that BPA exposure decreased the expression of gonadal soma-derived factor (gsdf) and increased liver vitellogenin (vtg) expression in a dose-dependent manner, suggesting these factors could serve as useful biomarkers for assessing the impact of estrogenic endocrine disruptors in