Publications by authors named "Mitsuru Dohke"
Article Synopsis
- - This study explores the link between retinal vascular area (VAFP) and arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV), using a deep-learning algorithm on retinal photos from 372 individuals.
- - Results show that both total arteriolar area (AA) and total venular area (VA) are negatively correlated with baPWV, indicating that larger retinal vessel areas may be associated with lower arterial stiffness.
- - The findings suggest that retinal vessel measurements could be used as a potential biomarker for assessing systemic arterial stiffness, establishing a significant relationship between retinal images and cardiovascular health.
Fat accumulation in the liver, pancreas, skeletal muscle, and visceral bed relates to type 2 diabetes (T2D). However, the distribution of fat among these compartments is heterogenous and whether specific distribution patterns indicate high T2D risk is unclear. We therefore investigated fat distribution patterns and their link to future T2D.
View Article and Find Full Text PDFArticle Synopsis
- A novel deep learning algorithm was developed to evaluate retinal vessel changes due to hypertension by analyzing fundus photographs from over 5,500 health-check participants.
- The study involved automatic extraction and categorization of retinal arterioles and venules, measuring their areas, and correlating these with age and blood pressure.
- Results showed significant correlations between the areas of arterioles and venules, with both areas negatively correlating with age and blood pressure, suggesting the algorithm could serve as a new indicator of hypertension-related vascular changes.
Background & Aims: Improvement of fatty liver may be required for remission of type-2 diabetes. However, there is no longitudinal evidence on whether fatty liver reduces the chances for remission of type-2 diabetes. We investigated the association between fatty liver and remission of type-2 diabetes (the primary analysis), and also the association between improvement of fatty liver and remission of type-2 diabetes (the secondary analysis).
View Article and Find Full Text PDFBackground: Only a few studies have longitudinally evaluated whether fatty pancreas increases the risk of type-2 diabetes (T2D), and their results were inconsistent. Fatty pancreas is closely linked to overweight and obesity, but previous studies did not exclude overweight or obese individuals. Therefore, in this cohort study, we investigated the association between fatty pancreas and T2D incidence in lean individuals.
View Article and Find Full Text PDFBackground And Aim: Previous cross-sectional studies showed that pancreatic fat was associated with metabolic syndrome. However, no longitudinal study has evaluated whether people with high pancreatic fat are likely to develop future metabolic syndrome. This study investigated the association between baseline pancreatic fat and metabolic syndrome incidence.
View Article and Find Full Text PDFBackground: The association between pancreatic fat and glucose dysmetabolism has been reported in several cross-sectional studies; however, a recent longitudinal study showed that baseline pancreatic fat did not cause subsequent diabetes mellitus. We hypothesized that pancreatic fat is not a cause but a manifestation of glucose dysmetabolism and aimed to investigate the association between baseline prediabetes and future pancreatic fat accumulation.
Methods: Between 2008 and 2015, 198 nondiabetic participants, who underwent a health check-up via unenhanced computed tomography (CT) twice with CT intervals ≥ 5 years, were enrolled as prediabetes (n = 48) and non-prediabetes participants (n = 150).
Objective: Previous cross-sectional studies have shown that attenuation in the pancreas seen on unenhanced computed tomography (CT) scans was inversely correlated with histologic pancreatic fat, and that fatty pancreas was associated with type 2 diabetes mellitus (T2DM). However, no longitudinal study has evaluated whether fatty pancreas increases the incidence of T2DM. We conducted a cohort study to investigate the association between fatty pancreas and the incidence of T2DM.
View Article and Find Full Text PDFObjective: Only a few studies have evaluated the long-term effects of nonalcoholic fatty liver disease (NAFLD) on type 2 diabetes mellitus (T2DM), and none have examined whether NAFLD improvement reduces T2DM incidence. We investigated the association between NAFLD improvement and T2DM incidence.
Research Design And Methods: Between 2000 and 2012, 4,604 participants who underwent a health check twice with >10 years between were enrolled.