Publications by authors named "Mitsuro Chiba"

Diet-related cardiometabolic diseases and inflammatory bowel disease, common previously in Western countries, are global problems. We hypothesized that inflammatory bowel disease is a lifestyle disease primarily mediated by the current Western diet. We report here the simultaneous onset of ulcerative colitis and autoimmune pancreatitis, a rare systemic complication of inflammatory bowel disease, 2 months after acute myocardial infarction in a patient with type 2 diabetes.

View Article and Find Full Text PDF

Background: We assert that the ubiquitous environmental factor in inflammatory bowel disease (IBD) is our westernized diet. Therefore, all of our newly diagnosed patients were admitted to experience a plant-based diet (PBD). In the present study, we investigated the efficacy of a PBD in pregnant women with IBD.

View Article and Find Full Text PDF

Identification and recognition of the ubiquitous environmental factor are prerequisite for treatment and prevention of the disease. The biggest problem with current practice in inflammatory bowel disease (IBD) is the lack of a widely appreciated ubiquitous environmental factor for the disease. The incidence of IBD is associated with dietary transition from a traditional diet to the current (westernized) diet.

View Article and Find Full Text PDF

There has been no study of the therapeutic effect of a plant-based diet (PBD) in inflammatory bowel disease (IBD) except for our studies in Japan. In this review, we describe the rationale for the requirement of PBD in IBD and the outcomes of our modality incorporating PBD together with a literature review. The biggest problem in current therapy for IBD is the lack of a widely appreciated ubiquitous environmental factor in IBD.

View Article and Find Full Text PDF

Introduction Incorporation of a plant-based diet was effective in both induction and short-term relapse prevention in Crohn's disease. Ten-year long-term relapse-free rates in Crohn's disease are around 10% to 23%. Objective We investigated whether infliximab and plant-based diet as first-line therapy enhance the long-term relapse-free rate in patients with Crohn's disease.

View Article and Find Full Text PDF

Introduction: We regard inflammatory bowel disease as a lifestyle disease mainly mediated by a westernized diet. We developed a plant-based diet (PBD) to counter the westernized diet. PBD can induce remission without medication in a subset of mild cases of ulcerative colitis.

View Article and Find Full Text PDF

Introduction: Inflammatory bowel disease has become a global disease, but its key environmental factors still remain unrecognized. This study aimed to clarify the role of dietary transition (westernization) in the increased incidence of inflammatory bowel disease in Japan.

Methods: Annual numbers of new cases of inflammatory bowel disease in Japan over the period from 1965 to 2000 found in a nationwide database compiled by the government and the daily amount of food and nutrient intake per capita for the same period revealed by the National Nutrition Survey have been used to analyze their interrelation.

View Article and Find Full Text PDF

Introduction: About one-third of patients with severe ulcerative colitis (UC) do not respond to corticosteroid therapy and receive rescue therapy with infliximab or cyclosporine. Up to 20% of such patients fail to respond to rescue therapy and undergo colectomy.

Objective: We investigated the outcomes of infliximab and a plant-based diet (PBD) as first-line therapy for severe UC.

View Article and Find Full Text PDF

We describe a scarcely reported case in which ulcerative colitis (UC) occurred in the postpartum period. The aims of this case report are to reinforce the recent assertion that a diet is a ubiquitous environmental factor in inflammatory bowel disease (IBD) and that a plant-based diet (PBD) is recommended for IBD. A 29-year-old woman normally delivered her first child.

View Article and Find Full Text PDF

Nonalcoholic fatty liver disease (NAFLD) develops in ulcerative colitis (UC) and Crohn's disease. However, there is scarce reporting on the onset of UC in patients with NAFLD. A 44-year-old man was diagnosed with UC and referred to us in 2019.

View Article and Find Full Text PDF

Context: No known previous study has focused on plant-based diet (PBD) to prevent relapse of ulcerative colitis (UC) except our previous educational hospitalization study.

Objective: To describe the relapse rate in a large case series of UC after incorporation of PBD into induction therapy.

Design: All patients with UC between 2003 and 2017 were admitted for induction therapy.

View Article and Find Full Text PDF
Article Synopsis
  • * Both patients were 21-year-old men with newly diagnosed Crohn's disease suffering from abdominal pain and diarrhea, but showed no prior bowel obstruction symptoms; imaging showed narrowed areas in the terminal ileum.
  • * Following infliximab treatment, the patients initially improved but developed abdominal distension and required surgical intervention due to obstruction, highlighting the need for awareness of this risk in patients with intestinal strictures.
View Article and Find Full Text PDF

Inflammatory bowel disease (IBD), a collective term for Crohn disease and ulcerative colitis, is a polygenic disease thought to be triggered by environmental factors. A Western or westernized lifestyle may be a major driver of the growing incidence of IBD. IBD may represent dysregulated mucosal inflammation to gut microbiota.

View Article and Find Full Text PDF

Context: No known published study has focused on a plant-based diet (PBD) in the treatment of ulcerative colitis (UC).

Objective: To investigate relapse prevention in UC after consumption of a PBD during educational hospitalization in Japan.

Design: Prospective study of patients with mild UC or UC in remission who did not need immediate treatment.

View Article and Find Full Text PDF

Background: Approximately 30% of patients with Crohn disease (CD) are unresponsive to biologics. No previous study has focused on a plant-based diet in an induction phase of CD treatment.

Objective: To investigate the remission rate of infliximab combined with a plant-based diet as first-line (IPF) therapy for CD.

View Article and Find Full Text PDF

Synopsis of recent research by authors named "Mitsuro Chiba"

  • Recent research by Mitsuro Chiba focuses on the intersection of diet and inflammatory bowel disease (IBD), specifically examining how a plant-based diet (PBD) can be effective in treating conditions such as ulcerative colitis and Crohn's disease.
  • Chiba's studies suggest that a westernized diet is a significant environmental factor contributing to the increasing incidence of IBD, asserting that dietary changes, particularly towards a PBD, can induce remission and improve therapeutic outcomes.
  • His findings indicate that the combined use of infliximab and a PBD as first-line therapy shows promising results in achieving high remission rates and preventing relapses in patients with severe ulcerative colitis and Crohn's disease.